Comparison of serum markers for allergic bronchopulmonary aspergillosis in cystic fibrosis

Latzin, P; Hartl, D; Regamey, N; Frey, U; Schoeni, M H; Casaulta, C (2008). Comparison of serum markers for allergic bronchopulmonary aspergillosis in cystic fibrosis. European respiratory journal, 31(1), pp. 36-42. Sheffield, UK: European Respiratory Society 10.1183/09031936.00078107

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The diagnosis of allergic bronchopulmonary aspergillosis (ABPA) in cystic fibrosis (CF) is a challenge. Thymus- and activation-regulated chemokine (TARC) has recently been reported to play a role in ABPA. The aim of this study was to compare the diagnostic value of TARC with that of known serological markers for diagnosis of ABPA in CF patients. The present study longitudinally followed 48 CF patients, of whom 12 had a diagnosis of ABPA according to Nelson's criteria, for 1-8 yrs with repeated measurements of serum total immunoglobulin (Ig)E, specific Aspergillus fumigatus IgE and IgG, specific IgE against recombinant A. fumigatus allergens (rAsp f) 1, 3, 4 and 6, and TARC. Median (interquartile range) TARC levels were 589 (465-673) pg x mL(-1) in ABPA patients and 232 (189-289) pg x mL(-1) in non-ABPA patients. Receiver operating characteristic curves revealed that TARC was superior to the other markers for diagnosis of ABPA. Diagnostic accuracy was greater for TARC (93%) than for total IgE (74%), or rAsp f 4 (75%) or f 6 (79%). The present study indicates that thymus- and activation-regulated chemokine may be useful in the diagnosis of allergic bronchopulmonary aspergillosis in cystic fibrosis patients. However, larger studies are needed before thymus- and activation-regulated chemokine can routinely be used in diagnostic algorithms.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Paediatric Medicine

UniBE Contributor:

Latzin, Philipp; Regamey, Nicolas; Frey, Urs Peter and Schöni, Martin Heinrich

ISSN:

0903-1936

ISBN:

17898016

Publisher:

European Respiratory Society

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:52

Last Modified:

17 Mar 2015 21:56

Publisher DOI:

10.1183/09031936.00078107

PubMed ID:

17898016

Web of Science ID:

000252390800008

URI:

https://boris.unibe.ch/id/eprint/22047 (FactScience: 29516)

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