Mycobacterium avium subspecies paratuberculosis and Crohn's disease: a systematic review and meta-analysis

Feller, Martin; Huwiler, Karin; Stephan, Roger; Altpeter, Ekkehardt; Shang, Aijing; Furrer, Hansjakob; Pfyffer, Gaby E; Jemmi, Thomas; Baumgartner, Andreas; Egger, Matthias (2007). Mycobacterium avium subspecies paratuberculosis and Crohn's disease: a systematic review and meta-analysis. Lancet infectious diseases, 7(9), pp. 607-613. London: Elsevier 10.1016/S1473-3099(07)70211-6

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This systematic review assesses the evidence for an association between Mycobacterium avium subspecies paratuberculosis (MAP) and Crohn's disease. We analysed 28 case-control studies comparing MAP in patients with Crohn's disease with individuals free of inflammatory bowel disease (IBD) or patients with ulcerative colitis. Compared with individuals free of IBD, the pooled odds ratio (OR) from studies using PCR in tissue samples was 7.01 (95% CI 3.95-12.4) and was 1.72 (1.02-2.90) in studies using ELISA in serum. ORs were similar for comparisons with ulcerative colitis patients (PCR, 4.13 [1.57-10.9]; ELISA, 1.88 [1.26-2.81]). The association of MAP with Crohn's disease seems to be specific, but its role in the aetiology of Crohn's disease remains to be defined.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Social and Preventive Medicine
04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Clinic of Infectiology

UniBE Contributor:

Feller, Martin; Huwiler, Karin; Shang, Aijing; Furrer, Hansjakob and Egger, Matthias

Subjects:

600 Technology > 610 Medicine & health
300 Social sciences, sociology & anthropology > 360 Social problems & social services

ISSN:

1473-3099

ISBN:

17714674

Publisher:

Elsevier

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:52

Last Modified:

01 Dec 2015 10:27

Publisher DOI:

10.1016/S1473-3099(07)70211-6

PubMed ID:

17714674

Web of Science ID:

000249091700018

BORIS DOI:

10.7892/boris.22095

URI:

https://boris.unibe.ch/id/eprint/22095 (FactScience: 30406)

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