The protease inhibitor alpha-2-macroglobulin-like-1 is the p170 antigen recognized by paraneoplastic pemphigus autoantibodies in human

Schepens, Isabelle; Jaunin, Fabienne; Begre, Nadja; Läderach, Ursula; Marcus, Katrin; Hashimoto, Takashi; Favre, Bertrand; Borradori, Luca (2010). The protease inhibitor alpha-2-macroglobulin-like-1 is the p170 antigen recognized by paraneoplastic pemphigus autoantibodies in human. PLoS ONE, 5(8), e12250. Lawrence, Kans.: Public Library of Science 10.1371/journal.pone.0012250

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Paraneoplastic pemphigus (PNP) is a devastating autoimmune blistering disease, involving mucocutaneous and internal organs, and associated with underlying neoplasms. PNP is characterized by the production of autoantibodies targeting proteins of the plakin and cadherin families involved in maintenance of cell architecture and tissue cohesion. Nevertheless, the identity of an antigen of Mr 170,000 (p170), thought to be critical in PNP pathogenesis, has remained unknown.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > Forschungsbereich Pathologie > Forschungsgruppe Dermatologie
04 Faculty of Medicine > Department of Dermatology, Urology, Rheumatology, Nephrology, Osteoporosis (DURN) > Clinic of Dermatology

UniBE Contributor:

Schepens, Isabelle; Läderach, Ursula; Favre, Bertrand and Borradori, Luca

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1932-6203

Publisher:

Public Library of Science

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:12

Last Modified:

12 Dec 2014 12:02

Publisher DOI:

10.1371/journal.pone.0012250

PubMed ID:

20805888

Web of Science ID:

000281011600022

BORIS DOI:

10.7892/boris.2261

URI:

https://boris.unibe.ch/id/eprint/2261 (FactScience: 204652)

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