Schepens, Isabelle; Jaunin, Fabienne; Begre, Nadja; Läderach, Ursula; Marcus, Katrin; Hashimoto, Takashi; Favre, Bertrand; Borradori, Luca (2010). The protease inhibitor alpha-2-macroglobulin-like-1 is the p170 antigen recognized by paraneoplastic pemphigus autoantibodies in human. PLoS ONE, 5(8), e12250. Lawrence, Kans.: Public Library of Science 10.1371/journal.pone.0012250
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Paraneoplastic pemphigus (PNP) is a devastating autoimmune blistering disease, involving mucocutaneous and internal organs, and associated with underlying neoplasms. PNP is characterized by the production of autoantibodies targeting proteins of the plakin and cadherin families involved in maintenance of cell architecture and tissue cohesion. Nevertheless, the identity of an antigen of Mr 170,000 (p170), thought to be critical in PNP pathogenesis, has remained unknown.
Item Type: |
Journal Article (Original Article) |
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Division/Institute: |
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > Forschungsbereich Pathologie > Forschungsgruppe Dermatologie 04 Faculty of Medicine > Department of Dermatology, Urology, Rheumatology, Nephrology, Osteoporosis (DURN) > Clinic of Dermatology |
UniBE Contributor: |
Schepens, Isabelle, Läderach, Ursula, Favre, Bertrand, Borradori, Luca |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
1932-6203 |
Publisher: |
Public Library of Science |
Language: |
English |
Submitter: |
Factscience Import |
Date Deposited: |
04 Oct 2013 14:12 |
Last Modified: |
05 Dec 2022 14:01 |
Publisher DOI: |
10.1371/journal.pone.0012250 |
PubMed ID: |
20805888 |
Web of Science ID: |
000281011600022 |
BORIS DOI: |
10.7892/boris.2261 |
URI: |
https://boris.unibe.ch/id/eprint/2261 (FactScience: 204652) |
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