Stucki, A; Cottagnoud, M; Winkelmann, V; Schaffner, T; Cottagnoud, P (2007). Daptomycin produces an enhanced bactericidal activity compared to ceftriaxone, measured by [3H]choline release in the cerebrospinal fluid, in experimental meningitis due to a penicillin-resistant pneumococcal strain without lysing its cell wall. Antimicrobial agents and chemotherapy, 51(6), pp. 2249-52. Washington, D.C.: American Society for Microbiology 10.1128/AAC.01000-06
Full text not available from this repository.Daptomycin monotherapy was superior to ceftriaxone monotherapy and was highly efficacious in experimental pneumococcal meningitis, sterilizing the cerebrospinal fluid (CSF) of three of three rabbits after 4 to 6 h. With daptomycin therapy only a negligible release of [(3)H]choline as marker of cell wall lysis was detectable in the CSF, peaking around 250 cpm/min after 4 h, compared to a peak of around 2,400 cpm/min after 4 to 6 h for the ceftriaxone-treated rabbits.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Department of General Internal Medicine (DAIM) > Clinic of General Internal Medicine > Centre of Competence for General Internal Medicine 04 Faculty of Medicine > Service Sector > Institute of Pathology 04 Faculty of Medicine > Department of General Internal Medicine (DAIM) > Clinic of General Internal Medicine |
UniBE Contributor: |
Stucki, Armin Niklaus, Schaffner, Thomas, Cottagnoud, Philippe |
ISSN: |
0066-4804 |
ISBN: |
17371817 |
Publisher: |
American Society for Microbiology |
Language: |
English |
Submitter: |
Factscience Import |
Date Deposited: |
04 Oct 2013 14:54 |
Last Modified: |
05 Dec 2022 14:16 |
Publisher DOI: |
10.1128/AAC.01000-06 |
PubMed ID: |
17371817 |
Web of Science ID: |
000246991400061 |
URI: |
https://boris.unibe.ch/id/eprint/22804 (FactScience: 37032) |
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