Stucki, A; Cottagnoud, M; Winkelmann, V; Schaffner, T; Cottagnoud, P (2007). Daptomycin produces an enhanced bactericidal activity compared to ceftriaxone, measured by [3H]choline release in the cerebrospinal fluid, in experimental meningitis due to a penicillin-resistant pneumococcal strain without lysing its cell wall. Antimicrobial agents and chemotherapy, 51(6), pp. 2249-52. Washington, D.C.: American Society for Microbiology 10.1128/AAC.01000-06
Full text not available from this repository. (Request a copy)Daptomycin monotherapy was superior to ceftriaxone monotherapy and was highly efficacious in experimental pneumococcal meningitis, sterilizing the cerebrospinal fluid (CSF) of three of three rabbits after 4 to 6 h. With daptomycin therapy only a negligible release of [(3)H]choline as marker of cell wall lysis was detectable in the CSF, peaking around 250 cpm/min after 4 h, compared to a peak of around 2,400 cpm/min after 4 to 6 h for the ceftriaxone-treated rabbits.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Department of General Internal Medicine (DAIM) > Clinic of General Internal Medicine > Centre of Competence for General Internal Medicine 04 Faculty of Medicine > Service Sector > Institute of Pathology 04 Faculty of Medicine > Department of General Internal Medicine (DAIM) > Clinic of General Internal Medicine |
UniBE Contributor: |
Stucki, Armin Niklaus, Schaffner, Thomas, Cottagnoud, Philippe |
ISSN: |
0066-4804 |
ISBN: |
17371817 |
Publisher: |
American Society for Microbiology |
Language: |
English |
Submitter: |
Factscience Import |
Date Deposited: |
04 Oct 2013 14:54 |
Last Modified: |
05 Dec 2022 14:16 |
Publisher DOI: |
10.1128/AAC.01000-06 |
PubMed ID: |
17371817 |
Web of Science ID: |
000246991400061 |
URI: |
https://boris.unibe.ch/id/eprint/22804 (FactScience: 37032) |
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