Tumour suppressors in liver carcinogenesis

Dufour, Jean-François; Huber, Otmar; Kozma, Sara C; Lu, Xin; Toftgård, Rune (2007). Tumour suppressors in liver carcinogenesis. Journal of hepatology, 47(6), pp. 860-7. Amsterdam: Elsevier 10.1016/j.jhep.2007.09.003

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The circuitous cell signalling pathways of hepatocytes comprise several factors that operate to downgrade or even interrupt the transmission of a given signal. These down-regulating influences are essential to keep cell proliferation and cell survival in check and if impaired, can alter a delicate balance in favour of cell proliferation. Each signalling pathway that has been implicated in carcinogenesis is influenced by both oncogenic factors that promote tumour growth when activated as well as tumour suppressor proteins that have to be impaired to favour tumour growth. This summary of the Tumour Suppressors in Liver Carcinogenesis Symposium held at the 2007 EASL Annual Meeting discusses four pathways with pre-eminent tumour suppressor activity, each involved in hepatocarcinogenesis: p53, mTOR, beta-catenin and hedgehog.

Item Type:

Journal Article (Further Contribution)

Division/Institute:

04 Faculty of Medicine > Department of Gastro-intestinal, Liver and Lung Disorders (DMLL) > Clinic of Visceral Surgery and Medicine > Hepatology

UniBE Contributor:

Dufour, Jean-François

ISSN:

0168-8278

ISBN:

17935820

Publisher:

Elsevier

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:54

Last Modified:

04 May 2014 23:15

Publisher DOI:

10.1016/j.jhep.2007.09.003

PubMed ID:

17935820

Web of Science ID:

000251491600016

URI:

https://boris.unibe.ch/id/eprint/22923 (FactScience: 37746)

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