[Anti-interleukin-5 therapy for eosinophilic diseases]

Simon, D; Braathen, L R; Simon, H-U (2007). [Anti-interleukin-5 therapy for eosinophilic diseases]. Hautarzt, 58(2), 122, 124-7. Heidelberg: Springer-Verlag 10.1007/s00105-006-1273-x

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In a number of diseases with eosinophilia, elevated interleukin (IL)-5 levels are detected in the peripheral blood and/or tissues. IL-5 plays an important role in regulating the production, differentiation, recruitment, activation, and survival of eosinophils. Therefore, neutralizing IL-5 by blocking antibodies seems a promising approach in the treatment of eosinophilic diseases. Clinical trials have demonstrated that anti-IL-5 therapy results in a rapid decrease in peripheral blood eosinophil numbers. Moreover, improvement of symptoms in patients with lymphocytic variants of hypereosinophilic syndromes, in eosinophilic esophagitis and chronic rhinitis with nasal polyposis has been observed. In contrast, in patients with bronchial asthma or atopic eczema, anti-IL-5 therapy showed only moderate or no clinical effects. Future studies will have to identify those eosinophilic diseases in which anti-IL-5 antibodies are effective, perhaps with the help of newly developed biomarkers.

Item Type:

Journal Article (Further Contribution)

Division/Institute:

04 Faculty of Medicine > Department of Dermatology, Urology, Rheumatology, Nephrology, Osteoporosis (DURN) > Clinic of Dermatology
04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Pharmacology

UniBE Contributor:

Simon, Dagmar and Simon, Hans-Uwe

ISSN:

0017-8470

ISBN:

17221241

Publisher:

Springer-Verlag

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:54

Last Modified:

26 Jun 2018 14:45

Publisher DOI:

10.1007/s00105-006-1273-x

PubMed ID:

17221241

Web of Science ID:

000244395100009

BORIS DOI:

10.7892/boris.23013

URI:

https://boris.unibe.ch/id/eprint/23013 (FactScience: 38551)

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