Autophagic-like cell death in neutrophils induced by autoantibodies

von Gunten, Stephan; Simon, Hans-Uwe (2007). Autophagic-like cell death in neutrophils induced by autoantibodies. Autophagy, 3(1), pp. 67-8. Austin, Tex.: Landes Bioscience

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Human neutrophils undergo autophagic-like cell death following Sialic acid binding immunoglobulin-like lectin-9 (Siglec-9) ligation and concurrent stimulation with certain, but not all, neutrophil survival cytokines. Caspase inhibition by these cytokines is required, but is not sufficient, to trigger this particular form of cell death. Additional mechanisms may involve reactive oxygen species (ROS), and blocking of ROS or prevention of ROS production prevents autophagic-like neutrophil death. Interestingly, human intravenous immunoglobulin (IVIg) preparations contain natural anti-Siglec-9 autoantibodies, which are able to ligate Siglec-9 on neutrophils and induce autophagic-like cell death in the presence of granulocyte-macrophage colony-stimulating factor (GM-CSF) and some other survival cytokines. Here, we discuss the pathophysiological and therapeutic implications of these recent findings.

Item Type:

Journal Article (Further Contribution)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Pharmacology

UniBE Contributor:

von Gunten, Stephan and Simon, Hans-Uwe

ISSN:

1554-8627

ISBN:

17102587

Publisher:

Landes Bioscience

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:54

Last Modified:

04 May 2014 23:15

PubMed ID:

17102587

Web of Science ID:

000243499200020

URI:

https://boris.unibe.ch/id/eprint/23015 (FactScience: 38555)

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