Interactions of nanoparticles with pulmonary structures and cellular responses

Muhlfeld, C; Rothen-Rutishauser, B; Blank, F; Vanhecke, D; Ochs, M; Gehr, P (2008). Interactions of nanoparticles with pulmonary structures and cellular responses. American journal of physiology - lung cellular and molecular physiology, 294(5), L817-L829. Bethesda, Md.: American Physiological Society 10.1152/ajplung.00442.2007

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Combustion-derived and synthetic nano-sized particles (NSP) have gained considerable interest among pulmonary researchers and clinicians for two main reasons: 1) Inhalation exposure to combustion-derived NSP was associated with increased pulmonary and cardiovascular morbidity and mortality as suggested by epidemiological studies. Experimental evidence has provided a mechanistic picture of the adverse health effects associated with inhalation of combustion-derived and synthetic NSP. 2) The toxicological potential of NSP contrasts with the potential application of synthetic NSP in technological as well as medicinal settings with the latter including the use of NSP as diagnostics or therapeutics. In order to shed light on this paradox, this article aims to highlight recent findings about the interaction of inhaled NSP with the structures of the respiratory tract including surfactant and alveolar macrophages and epithelial cells. Cellular responses to NSP exposure include the generation of reactive oxygen species and the induction of an inflammatory response. Furthermore, this review places special emphasis on methodological differences between experimental studies and the caveats associated with the dose metrics and points out ways to overcome inherent methodological problems. Key words: electron tomography, surfactant, translocation, oxidative stress, inflammation.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Anatomy > Topographical and Clinical Anatomy
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > Forschungsbereich Mu50 > Forschungsgruppe Pneumologie (Erwachsene)
04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Anatomy

UniBE Contributor:

Mühlfeld, Christian; Rothen-Rutishauser, Barbara; Blank, Fabian; Vanhecke, Dimitri; Ochs, Matthias and Gehr, Peter

ISSN:

1040-0605

ISBN:

18263666

Publisher:

American Physiological Society

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:55

Last Modified:

08 Jun 2016 10:43

Publisher DOI:

10.1152/ajplung.00442.2007

PubMed ID:

18263666

Web of Science ID:

000255501400001

URI:

https://boris.unibe.ch/id/eprint/23512 (FactScience: 42168)

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