Mechanotransduction in striated muscle via focal adhesion kinase

Durieux, A C; Desplanches, D; Freyssenet, D; Flück, M (2007). Mechanotransduction in striated muscle via focal adhesion kinase. Biochemical Society transactions, 35(Pt 5), pp. 1312-3. London: Portland Press

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Contractile tissues demonstrate a pronounced capacity to remodel their composition in response to mechanical challenges. Descriptive evidence suggests the upstream involvement of the phosphotransfer enzyme FAK (focal adhesion kinase) in the molecular control of load-dependent muscle plasticity. Thereby FAK evolves as a myocellular transducer of mechanical signals towards downstream transcript expression in myofibres. Recent advances in somatic gene therapy now allow the exploration of the functional involvement of this enzyme in mechanotransduction in intact muscle.

Item Type:

Journal Article (Further Contribution)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Anatomy > Functional Anatomy

UniBE Contributor:

Durieux, Anne Cécile and Flück, Martin

ISSN:

0300-5127

ISBN:

17956339

Publisher:

Portland Press

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:55

Last Modified:

04 May 2014 23:16

PubMed ID:

17956339

Web of Science ID:

000251279800111

URI:

https://boris.unibe.ch/id/eprint/23532 (FactScience: 42221)

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