Durieux, A C; Desplanches, D; Freyssenet, D; Flück, M (2007). Mechanotransduction in striated muscle via focal adhesion kinase. Biochemical Society transactions, 35(Pt 5), pp. 1312-3. London: Portland Press
Full text not available from this repository. (Request a copy)Contractile tissues demonstrate a pronounced capacity to remodel their composition in response to mechanical challenges. Descriptive evidence suggests the upstream involvement of the phosphotransfer enzyme FAK (focal adhesion kinase) in the molecular control of load-dependent muscle plasticity. Thereby FAK evolves as a myocellular transducer of mechanical signals towards downstream transcript expression in myofibres. Recent advances in somatic gene therapy now allow the exploration of the functional involvement of this enzyme in mechanotransduction in intact muscle.
Item Type: |
Journal Article (Further Contribution) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Anatomy > Functional Anatomy |
UniBE Contributor: |
Durieux, Anne Cécile, Flück, Martin |
ISSN: |
0300-5127 |
ISBN: |
17956339 |
Publisher: |
Portland Press |
Language: |
English |
Submitter: |
Factscience Import |
Date Deposited: |
04 Oct 2013 14:55 |
Last Modified: |
05 Dec 2022 14:17 |
PubMed ID: |
17956339 |
Web of Science ID: |
000251279800111 |
URI: |
https://boris.unibe.ch/id/eprint/23532 (FactScience: 42221) |
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