Hippocampal functional connectivity reflects verbal episodic memory network integrity

Wagner, Kathrin; Frings, Lars; Halsband, Ulrike; Everts, Regula; Buller, Anne; Spreer, Joachim; Zentner, Josef; Schulze-Bonhage, Andreas (2007). Hippocampal functional connectivity reflects verbal episodic memory network integrity. NeuroReport, 18(16), pp. 1719-23. London: Lippincott Williams & Wilkins 10.1097/WNR.0b013e3282f0d3c5

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Using functional magnetic resonance imaging during a verbal memory task, we investigated correlations of signal fluctuations within the hippocampus and ipsilateral frontal as well as temporal areas in temporal lobe epilepsy patients. Declarative memory abilities were additionally examined before and after temporal lobe epilepsy surgery. A significant difference exists in functional connectivity between patients whose mnemonic functions deteriorated and those who remained stable or improved. Univariate analyses showed significantly higher preoperative coupling between the hippocampus and Brodmann area 22 for the group that decreased in verbal learning. We suggest greater coupling to reflect higher functional network integrity. Postoperatively reduced learning ability in patients with higher preoperative coupling underlines the importance of hippocampal interaction with cortical areas for successful memory formation.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Paediatric Medicine

UniBE Contributor:

Everts, Regula

ISSN:

0959-4965

ISBN:

17921875

Publisher:

Lippincott Williams & Wilkins

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:55

Last Modified:

04 May 2014 23:16

Publisher DOI:

10.1097/WNR.0b013e3282f0d3c5

PubMed ID:

17921875

Web of Science ID:

000250329300017

URI:

https://boris.unibe.ch/id/eprint/23559 (FactScience: 42416)

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