Wagner, Kathrin; Frings, Lars; Halsband, Ulrike; Everts, Regula; Buller, Anne; Spreer, Joachim; Zentner, Josef; Schulze-Bonhage, Andreas (2007). Hippocampal functional connectivity reflects verbal episodic memory network integrity. NeuroReport, 18(16), pp. 1719-23. London: Lippincott Williams & Wilkins 10.1097/WNR.0b013e3282f0d3c5
Full text not available from this repository.Using functional magnetic resonance imaging during a verbal memory task, we investigated correlations of signal fluctuations within the hippocampus and ipsilateral frontal as well as temporal areas in temporal lobe epilepsy patients. Declarative memory abilities were additionally examined before and after temporal lobe epilepsy surgery. A significant difference exists in functional connectivity between patients whose mnemonic functions deteriorated and those who remained stable or improved. Univariate analyses showed significantly higher preoperative coupling between the hippocampus and Brodmann area 22 for the group that decreased in verbal learning. We suggest greater coupling to reflect higher functional network integrity. Postoperatively reduced learning ability in patients with higher preoperative coupling underlines the importance of hippocampal interaction with cortical areas for successful memory formation.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Paediatric Medicine |
UniBE Contributor: |
Everts, Regula |
ISSN: |
0959-4965 |
ISBN: |
17921875 |
Publisher: |
Lippincott Williams & Wilkins |
Language: |
English |
Submitter: |
Anette van Dorland |
Date Deposited: |
04 Oct 2013 14:55 |
Last Modified: |
05 Dec 2022 14:17 |
Publisher DOI: |
10.1097/WNR.0b013e3282f0d3c5 |
PubMed ID: |
17921875 |
Web of Science ID: |
000250329300017 |
URI: |
https://boris.unibe.ch/id/eprint/23559 (FactScience: 42416) |
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