Smith, Terry K; Bütikofer, Peter (2010). Lipid metabolism in Trypanosoma brucei. Molecular and biochemical parasitology, 172(2), pp. 66-79. Amsterdam: Elsevier 10.1016/j.molbiopara.2010.04.001
Full text not available from this repository.Trypanosoma brucei membranes consist of all major eukaryotic glycerophospholipid and sphingolipid classes. These are de novo synthesized from precursors obtained either from the host or from catabolised endocytosed lipids. In recent years, substantial progress has been made in the molecular and biochemical characterisation of several of these lipid biosynthetic pathways, using gene knockout or RNA interference strategies or by enzymatic characterization of individual reactions. Together with the completed genome, these studies have highlighted several possible differences between mammalian and trypanosome lipid biosynthesis that could be exploited for the development of drugs against the diseases caused by these parasites.
Item Type: |
Journal Article (Further Contribution) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Biochemistry and Molecular Medicine |
UniBE Contributor: |
Bütikofer, Peter |
ISSN: |
0166-6851 |
Publisher: |
Elsevier |
Language: |
English |
Submitter: |
Factscience Import |
Date Deposited: |
04 Oct 2013 14:12 |
Last Modified: |
05 Dec 2022 14:01 |
Publisher DOI: |
10.1016/j.molbiopara.2010.04.001 |
PubMed ID: |
20382188 |
Web of Science ID: |
000278907700002 |
URI: |
https://boris.unibe.ch/id/eprint/2415 (FactScience: 204906) |
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