Perrig, M; Acosta, F; Cottagnoud, M; Gerber, CM; Täuber, MG; Cottagnoud, P (2001). Efficacy of gatifloxacin alone and in combination with cefepime against penicillin-resistant Streptococcus pneumoniae in a rabbit meningitis model and in vitro. Journal of antimicrobial chemotherapy, 47(5), pp. 701-4. Oxford: Oxford University Press 10.1093/jac/47.5.701
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Gatifloxacin penetrated well into cerebrospinal fluid (CSF) (49 +/- 11%), measured by comparison of AUC(CSF)/AUC(serum), and showed good bactericidal activity (leading to a decrease of 0.75 +/- 0.17 log10 cfu/mL/h) in the treatment of experimental meningitis in rabbits caused by a penicillin-resistant pneumococcal strain (MIC 4 mg/L). It was significantly more effective than the standard regimen, ceftriaxone with vancomycin, which led to a decrease of 0.53 +/- 0.17 log10 cfu/mL/h. The addition of cefepime to gatifloxacin slightly improved the killing rates (giving a decrease of 0.84 +/- 0.14 log10 cfu/mL/h). In vitro, synergy was demonstrated between cefepime and gatifloxacin by the chequerboard method (fractional inhibitory concentration index = 0.5) and by viable counts over 8 h.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Service Sector > Institute for Infectious Diseases |
UniBE Contributor: |
Täuber, Martin G. |
ISSN: |
0305-7453 |
ISBN: |
11328789 |
Publisher: |
Oxford University Press |
Language: |
English |
Submitter: |
Factscience Import |
Date Deposited: |
04 Oct 2013 15:00 |
Last Modified: |
21 Feb 2023 15:37 |
Publisher DOI: |
10.1093/jac/47.5.701 |
PubMed ID: |
11328789 |
Web of Science ID: |
000168839000031 |
BORIS DOI: |
10.7892/boris.25742 |
URI: |
https://boris.unibe.ch/id/eprint/25742 (FactScience: 60852) |
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