Cottagnoud, P; Gerber, CM; Acosta, F; Cottagnoud, M; Neftel, K; Täuber, MG (2000). Linezolid against penicillin-sensitive and -resistant pneumococci in the rabbit meningitis model. Journal of antimicrobial chemotherapy, 46(6), pp. 981-5. Oxford: Oxford University Press 10.1093/jac/46.6.981
|
Text
0460981.pdf - Published Version Available under License Publisher holds Copyright. Download (107kB) | Preview |
Linezolid, a new oxazolidinone antibiotic, showed good penetration (38+/-4%) into the meninges of rabbits with levels in the CSF ranging from 9.5 to 1.8 mg/L after two i.v. injections (20 mg/kg). Linezolid was clearly less effective than ceftriaxone against a penicillin-sensitive pneumococcal strain. Against a penicillin-resistant strain, linezolid had slightly inferior killing rates compared with the standard regimen (ceftriaxone combined with vancomycin). In vitro, linezolid was marginally bactericidal at concentrations above the MIC (5 x and 10 x MIC).
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Service Sector > Institute for Infectious Diseases |
UniBE Contributor: |
Täuber, Martin G. |
ISSN: |
0305-7453 |
ISBN: |
11102418 |
Publisher: |
Oxford University Press |
Language: |
English |
Submitter: |
Factscience Import |
Date Deposited: |
04 Oct 2013 15:00 |
Last Modified: |
21 Feb 2023 15:38 |
Publisher DOI: |
10.1093/jac/46.6.981 |
PubMed ID: |
11102418 |
Web of Science ID: |
000166047000017 |
BORIS DOI: |
10.7892/boris.25745 |
URI: |
https://boris.unibe.ch/id/eprint/25745 (FactScience: 60858) |
Actions (login required)
 |
Edit item |