Gerber, CM; Tovar, L; Cottagnoud, M; Neftel, KA; Täuber, MG; Cottagnoud, P (2000). Grepafloxacin against penicillin-resistant pneumococci in the rabbit meningitis model. Journal of antimicrobial chemotherapy, 46(2), pp. 249-53. Oxford: Oxford University Press 10.1093/jac/46.2.249
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Grepafloxacin, a new fluoroquinolone, produced bactericidal activity comparable to that of vancomycin and ceftriaxone in the treatment in rabbits of meningitis caused by a pneumococcal strain highly resistant to penicillin (MIC 4 mg/L) (triangle uplog(10) cfu/mL*h for grepafloxacin, -0.32 +/- 0.15; dose, 15 mg/kg iv; triangle uplog(10) cfu/mL*h for vancomycin, -0.39 +/- 0.18; dose, 2 x 20 mg/kg iv; triangle uplog(10) cfu/mL*h for ceftriaxone, -0.32 +/- 0. 12; dose, 125 mg/kg iv). Higher doses of grepafloxacin (30 mg/kg and 2 x 50 mg/kg) did not improve the killing rates. The combination of grepafloxacin with vancomycin was not significantly superior to monotherapies (P > 0.05). In vitro, grepafloxacin was bactericidal at concentrations above the MIC. Using concentrations around the MIC, addition of vancomycin to grepafloxacin showed synergic activity.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Service Sector > Institute for Infectious Diseases |
UniBE Contributor: |
Täuber, Martin G. |
ISSN: |
0305-7453 |
ISBN: |
10933648 |
Publisher: |
Oxford University Press |
Language: |
English |
Submitter: |
Factscience Import |
Date Deposited: |
04 Oct 2013 15:00 |
Last Modified: |
21 Feb 2023 15:38 |
Publisher DOI: |
10.1093/jac/46.2.249 |
PubMed ID: |
10933648 |
Web of Science ID: |
000089309900013 |
BORIS DOI: |
10.7892/boris.25746 |
URI: |
https://boris.unibe.ch/id/eprint/25746 (FactScience: 60861) |
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