Cottagnoud, P; Acosta, F; Cottagnoud, M; Neftel, K; Täuber, MG (2000). Synergy between trovafloxacin and ceftriaxone against penicillin-resistant pneumococci in the rabbit meningitis model and in vitro. Antimicrobial agents and chemotherapy, 44(8), pp. 2179-81. Washington, D.C.: American Society for Microbiology 10.1128/AAC.44.8.2179-2181.2000
Full text not available from this repository.The bactericidal activities of monotherapy with trovafloxacin (-0.37 +/- 0.15 Delta log(10) CFU/ml. h), vancomycin (-0.32 +/- 0.12 Delta log(10) CFU/ml. h), and ceftriaxone (-0.36 +/- 0.19 Delta log(10) CFU/ml. h) for the treatment of experimental meningitis in rabbits due to a clinical penicillin-resistant pneumococcal strain (MIC, 4 mg/liter) were similar. The combination of ceftriaxone with trovafloxacin considerably improved the killing rates (-0.67 +/- 0.16 Delta log(10) CFU/ml. h) and was slightly superior to ceftriaxone with vancomycin (killing rate, -0.53 +/- 0. 22 Delta log(10) CFU/ml. h), the regimen most commonly used in clinical practice. In vitro, synergy was demonstrated between ceftriaxone and trovafloxacin by the checkerboard method (fractional inhibitory concentration index, 0.5) and by time-killing assays over 8 h.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Service Sector > Institute for Infectious Diseases |
UniBE Contributor: |
Täuber, Martin G. |
ISSN: |
0066-4804 |
ISBN: |
10898696 |
Publisher: |
American Society for Microbiology |
Language: |
English |
Submitter: |
Factscience Import |
Date Deposited: |
04 Oct 2013 15:00 |
Last Modified: |
05 Dec 2022 14:18 |
Publisher DOI: |
10.1128/AAC.44.8.2179-2181.2000 |
PubMed ID: |
10898696 |
Web of Science ID: |
000088308200029 |
URI: |
https://boris.unibe.ch/id/eprint/25748 (FactScience: 60865) |
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