Gerber, CM; Cottagnoud, M; Neftel, KA; Täuber, MG; Cottagnoud, P (1999). Meropenem alone and in combination with vancomycin in experimental meningitis caused by a penicillin-resistant pneumococcal strain. European journal of clinical microbiology & infectious diseases, 18(12), pp. 866-70. Berlin: Springer 10.1007/s100960050421
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In a rabbit model of meningitis caused by a pneumococcus highly resistant to penicillin (MIC, 4 microg/ml), meropenem, a broad-spectrum carbapenem, was bactericidal (-0.48+/-0.14 deltalog10 cfu/ml h) and slightly superior to ceftriaxone (-0.34+/-0.23 deltalog10 cfu/ml x h) and vancomycin (-0.39+/-0.19 deltalog10 cfu/ml x h). Although the combination of vancomycin with ceftriaxone was significantly more active than ceftriaxone alone (-0.55+/-0.19 deltalog10 cfu/ml x h), only an insignificant gain was observed by the addition of vancomycin to meropenem (-0.55+/-0.28 deltalog10 cfu/ml x h).
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Service Sector > Institute for Infectious Diseases |
UniBE Contributor: |
Täuber, Martin G. |
ISSN: |
0934-9723 |
ISBN: |
10691197 |
Publisher: |
Springer |
Language: |
English |
Submitter: |
Factscience Import |
Date Deposited: |
04 Oct 2013 15:00 |
Last Modified: |
05 Dec 2022 14:18 |
Publisher DOI: |
10.1007/s100960050421 |
PubMed ID: |
10691197 |
Web of Science ID: |
000085066100005 |
BORIS DOI: |
10.48350/25752 |
URI: |
https://boris.unibe.ch/id/eprint/25752 (FactScience: 60873) |
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