Experimental pneumococcal meningitis causes central nervous system pathology without inducing the 72-kd heat shock protein

Täuber, MG; Kennedy, SL; Tureen, JH; Lowenstein, DH (1992). Experimental pneumococcal meningitis causes central nervous system pathology without inducing the 72-kd heat shock protein. American journal of pathology, 141(1), pp. 53-60. New York, N.Y.: Elsevier

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We examined whether experimental pneumococcal meningitis induced the 72-kd heat shock protein (HSP72), a sensitive marker of neuronal stress in other models of central nervous system (CNS) injury. Brain injury was characterized by vasculitis, cerebritis, and abscess formation in the cortex of infected animals. The extent of these changes correlated with the size of the inoculum (P less than 0.003) and with pathophysiologic parameters of disease severity, i.e., cerebrospinal fluid (CSF) lactate (r = 0.61, P less than 0.0001) and CSF glucose concentrations (r = -0.55, P less than 0.0001). Despite the presence of numerous cortical regions having morphologic evidence of injury, HSP72 was not detected in most animals. When present, only rare neurons were HSP72 positive. Western blot analysis of brain samples confirmed the paucity of HSP72 induction. The lack of neuronal HSP72 expression in this model suggests that at least some of the events leading to neuronal injury in meningitis are unique, when compared with CNS diseases associated with HSP72 induction.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Service Sector > Institute for Infectious Diseases

UniBE Contributor:

Täuber, Martin G.

ISSN:

0002-9440

ISBN:

1632471

Publisher:

Elsevier

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 15:00

Last Modified:

17 Mar 2015 22:10

PubMed ID:

1632471

Web of Science ID:

A1992JC89800008

URI:

https://boris.unibe.ch/id/eprint/25796 (FactScience: 60962)

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