Effect of indomethacin on the pathophysiology of experimental meningitis in rabbits

Tureen, JH; Täuber, MG; Sande, MA (1991). Effect of indomethacin on the pathophysiology of experimental meningitis in rabbits. Journal of infectious diseases, 163(3), pp. 647-9. Cary, N.C.: Oxford University Press 10.1093/infdis/163.3.647

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The effects of indomethacin on central nervous system abnormalities in rabbits with experimental pneumococcal meningitis were studied. As expected, prostaglandin E2 levels in cerebrospinal fluid were significantly lower in the indomethacin-treated group, indicating that the drug effectively reduced prostaglandin synthesis. Brain edema was markedly attenuated in the indomethacin-treated group; however, cerebrospinal fluid white blood cell counts, lactate and protein concentrations, and intracisternal pressure were not significantly different between groups. It seems that indomethacin, while effective in reducing brain edema, does not significantly affect other important pathophysiologic alterations in experimental pneumococcal meningitis.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Service Sector > Institute for Infectious Diseases

UniBE Contributor:

Täuber, Martin G.

ISSN:

0022-1899

ISBN:

1995738

Publisher:

Oxford University Press

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 15:00

Last Modified:

04 May 2014 23:17

Publisher DOI:

10.1093/infdis/163.3.647

PubMed ID:

1995738

Web of Science ID:

A1991EY49500039

URI:

https://boris.unibe.ch/id/eprint/25801 (FactScience: 60975)

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