Experimental models of CNS infections. Contributions to concepts of disease and treatment

Täuber, MG; Brooks-Fournier, RA; Sande, MA (1986). Experimental models of CNS infections. Contributions to concepts of disease and treatment. Neurologic clinics, 4(1), pp. 249-64. New York, N.Y.: Elsevier

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Lessons learned from studies of experimental meningitis and brain abscess in animal models of infection represent major, highly significant contributions to our understanding of the pathogenesis and antimicrobial chemotherapy of these infections. For example, studies of experimental meningitis in rabbits demonstrated that the subarachnoid space is deficient in local host defenses, a finding that explains why only bactericidal antibiotic regimens are effective in treating this disease; studies of the efficacy of corticosteroids as adjunctive therapy for meningitis yielded data indicating that both beneficial and detrimental effects on the host are imparted by these compounds. These and a number of other key investigations of experimental meningitis and brain abscess, the results of these investigations, and the clinical significance of these results are presented in this article.

Item Type:	Journal Article (Further Contribution)
Division/Institute:	04 Faculty of Medicine > Service Sector > Institute for Infectious Diseases
UniBE Contributor:	Täuber, Martin G.
ISSN:	0733-8619
ISBN:	3523203
Publisher:	Elsevier
Language:	English
Submitter:	Factscience Import
Date Deposited:	04 Oct 2013 15:00
Last Modified:	05 Dec 2022 14:18
PubMed ID:	3523203
Web of Science ID:	A1986C498600013
URI:	https://boris.unibe.ch/id/eprint/25826 (FactScience: 61029)