New cephalosporins cefotaxime, cefpimizole, BMY 28142, and HR 810 in experimental pneumococcal meningitis in rabbits

Täuber, MG; Hackbarth, CJ; Scott, KG; Rusnak, MG; Sande, MA (1985). New cephalosporins cefotaxime, cefpimizole, BMY 28142, and HR 810 in experimental pneumococcal meningitis in rabbits. Antimicrobial agents and chemotherapy, 27(3), pp. 340-2. Washington, D.C.: American Society for Microbiology 10.1128/AAC.27.3.340

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Four new cephalosporins, cefotaxime, cefpimizole (U 63196E), BMY 28142, and HR 810 were evaluated in experimental pneumococcal meningitis. Cefotaxime penetrated only moderately into the cerebrospinal fluid of rabbits with meningitis, whereas cefpimizole, BMY 28142, and HR 810 all exhibited unusually good penetration. The bactericidal activity in infected cerebrospinal fluid was comparable for the four drugs.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Service Sector > Institute for Infectious Diseases

UniBE Contributor:

Täuber, Martin G.

ISSN:

0066-4804

ISBN:

3838872

Publisher:

American Society for Microbiology

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 15:00

Last Modified:

04 May 2014 23:18

Publisher DOI:

10.1128/AAC.27.3.340

PubMed ID:

3838872

Web of Science ID:

A1985ACW6000012

URI:

https://boris.unibe.ch/id/eprint/25832 (FactScience: 61041)

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