Oral sirolimus for prevention of recurrent infrainguinal arterial obstructions after surgical and endovascular revascularizations

Keo, H; Do, D; Husmann, M; Baumgartner, I (2008). Oral sirolimus for prevention of recurrent infrainguinal arterial obstructions after surgical and endovascular revascularizations. Vasa - European journal of vascular medicine, 37(3), pp. 285-8. Bern: Huber 10.1024/0301.1526.37.3.285

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No data are currently available on the role of oral sirolimus in the prevention of recurrent stenosis in the periphery. We report the effects of oral sirolimus in the prevention of recurrent infrainguinal obstructions in patients with complex peripheral arterial disease. Three patients with ischemic rest pain of the lower limbs and repeated short-term need for surgical and/or endovascular revascularization: 9 times within 12 months, 7 times within 15 months, 11 times within 26 months, respectively. Oral sirolimus on a case by case basis, resulted in less frequent restenosis and longer intervention-free intervals: three re-interventions within 37 months in the first patient, one balloon angioplasty within 17 months in the second, and three re-interventions within 21 months in the third patient, respectively. Side effects, in particular dyspepsia and diarrhoea, were mild and tolerable. To our knowledge, this is the first report to show that oral sirolimus was successfully administered in patients with recurrent excessive neointimal proliferation after revascularization of peripheral arterial lesions lowering the necessity of re-intervention and hence prolonging intervention-free intervals.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Cardiovascular Disorders (DHGE) > Clinic of Angiology

UniBE Contributor:

Keo, Hak Hong; Do, Dai-Do; Husmann, Marc and Baumgartner, Iris

ISSN:

0301-1526

ISBN:

285-8

Publisher:

Huber

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 15:02

Last Modified:

04 May 2014 23:18

Publisher DOI:

10.1024/0301.1526.37.3.285

Web of Science ID:

000259576000012

URI:

https://boris.unibe.ch/id/eprint/26885 (FactScience: 91616)

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