Sluijs, Koenraad F van der; Obregon, Carolina; Geiser, Thomas K; Mühlemann, Kathrin; Nicod, Laurent P (2011). Monocyte differentiation toward regulatory dendritic cells is not affected by respiratory syncytial virus-induced inflammatory mediators. American journal of respiratory cell and molecular biology, 44(5), pp. 655-64. New York, N.Y.: American Lung Association 10.1165/rcmb.2010-0136OC
Full text not available from this repository.Airway epithelial cells were shown to drive the differentiation of monocytes into dendritic cells (DCs) with a suppressive phenotype. In this study, we investigated the impact of virus-induced inflammatory mediator production on the development of DCs. Monocyte differentiation into functional DCs, as reflected by the expression of CD11c, CD123, BDCA-4, and DC-SIGN and the capacity to activate T cells, was similar for respiratory syncytial virus (RSV)-infected and mock-infected BEAS-2B and A549 cells. RSV-conditioned culture media resulted in a partially mature DC phenotype, but failed to up-regulate CD80, CD83, CD86, and CCR7, and failed to release proinflammatory mediators upon Toll-like receptor (TLR) triggering. Nevertheless, these DCs were able to maintain an antiviral response by the release of Type I IFN. Collectively, these data indicate that the airway epithelium maintains an important suppressive DC phenotype under the inflammatory conditions induced by infection with RSV.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Department of Gastro-intestinal, Liver and Lung Disorders (DMLL) > Clinic of Pneumology 04 Faculty of Medicine > Service Sector > Institute for Infectious Diseases |
UniBE Contributor: |
Geiser, Thomas (A), Mühlemann, Kathrin |
ISSN: |
1044-1549 |
Publisher: |
American Lung Association |
Language: |
English |
Submitter: |
Factscience Import |
Date Deposited: |
04 Oct 2013 14:12 |
Last Modified: |
29 Mar 2023 23:32 |
Publisher DOI: |
10.1165/rcmb.2010-0136OC |
PubMed ID: |
20595462 |
Web of Science ID: |
000293945500010 |
URI: |
https://boris.unibe.ch/id/eprint/2691 (FactScience: 205558) |
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