Monocyte differentiation toward regulatory dendritic cells is not affected by respiratory syncytial virus-induced inflammatory mediators

Sluijs, Koenraad F van der; Obregon, Carolina; Geiser, Thomas K; Mühlemann, Kathrin; Nicod, Laurent P (2011). Monocyte differentiation toward regulatory dendritic cells is not affected by respiratory syncytial virus-induced inflammatory mediators. American journal of respiratory cell and molecular biology, 44(5), pp. 655-64. New York, N.Y.: American Lung Association 10.1165/rcmb.2010-0136OC

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Airway epithelial cells were shown to drive the differentiation of monocytes into dendritic cells (DCs) with a suppressive phenotype. In this study, we investigated the impact of virus-induced inflammatory mediator production on the development of DCs. Monocyte differentiation into functional DCs, as reflected by the expression of CD11c, CD123, BDCA-4, and DC-SIGN and the capacity to activate T cells, was similar for respiratory syncytial virus (RSV)-infected and mock-infected BEAS-2B and A549 cells. RSV-conditioned culture media resulted in a partially mature DC phenotype, but failed to up-regulate CD80, CD83, CD86, and CCR7, and failed to release proinflammatory mediators upon Toll-like receptor (TLR) triggering. Nevertheless, these DCs were able to maintain an antiviral response by the release of Type I IFN. Collectively, these data indicate that the airway epithelium maintains an important suppressive DC phenotype under the inflammatory conditions induced by infection with RSV.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Gastro-intestinal, Liver and Lung Disorders (DMLL) > Clinic of Pneumology
04 Faculty of Medicine > Service Sector > Institute for Infectious Diseases

UniBE Contributor:

Geiser, Thomas and Mühlemann, Kathrin

ISSN:

1044-1549

Publisher:

American Lung Association

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:12

Last Modified:

17 Mar 2015 19:15

Publisher DOI:

10.1165/rcmb.2010-0136OC

PubMed ID:

20595462

Web of Science ID:

000293945500010

URI:

https://boris.unibe.ch/id/eprint/2691 (FactScience: 205558)

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