Lüer, Sonja; Berger, Steffen; Diepold, Miriam; Duppenthaler, Andrea; von Gunten, Michael; Mühlethaler, Konrad; Wolf, Rainer; Aebi, Christoph (2009). Treatment of intestinal and hepatic mucormycosis in an immunocompromized child. Pediatric blood & cancer, 52(7), pp. 872-4. Hoboken, N.J.: Wiley-Liss 10.1002/pbc.21918
Full text not available from this repository.During ALL chemotherapy, a 4-year-old patient presented with febrile neutropenia and abdominal pain. Ultrasound examinations were repeatedly normal. Computerized tomography on day 7 demonstrated appendicitis and multiple hepatic foci identified as mucormycosis (Absidia corymbifera). Successful outcome was achieved by aggressive re-surgery, long-term antifungal therapy with serum level-monitored posaconazole, and recovery of neutrophil counts. Considering the interference of posaconazole with CYP3A4, vincristine was administered during 72 hr posaconazole windows. Pediatric intestinal mucormycosis, still associated with a >70% case-fatality rate, calls for early imaging and surgery to establish the diagnosis, reduce the fungal mass, and provide a rationale for using posaconazole.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Paediatric Medicine 04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Paediatric Surgery 04 Faculty of Medicine > Service Sector > Institute of Pathology |
UniBE Contributor: |
Lüer, Sonja, Berger, Steffen Michael, Diepold, Miriam, Duppenthaler, Andrea, von Gunten, Michael, Aebi, Christoph |
ISSN: |
1545-5009 |
ISBN: |
19127570 |
Publisher: |
Wiley-Liss |
Language: |
English |
Submitter: |
Anette van Dorland |
Date Deposited: |
04 Oct 2013 15:02 |
Last Modified: |
02 Mar 2023 23:22 |
Publisher DOI: |
10.1002/pbc.21918 |
PubMed ID: |
19127570 |
Web of Science ID: |
000265346100027 |
URI: |
https://boris.unibe.ch/id/eprint/27153 (FactScience: 104796) |
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