Development of the premature infant nose throat-model (PrINT-Model): an upper airway replica of a premature neonate for the study of aerosol delivery

Minocchieri, Stefan; Burren, Juerg Martin; Bachmann, Marc Aurel; Stern, Georgette; Wildhaber, Johannes; Buob, Stefan; Schindel, Ralf; Kraemer, Richard; Frey, Urs Peter; Nelle, Mathias (2008). Development of the premature infant nose throat-model (PrINT-Model): an upper airway replica of a premature neonate for the study of aerosol delivery. Pediatric research, 64(2), pp. 141-6. New York, N.Y.: Nature Publishing Group 10.1203/PDR.0b013e318175dcfa

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Clinical efficacy of aerosol therapy in premature newborns depends on the efficiency of delivery of aerosolized drug to the bronchial tree. To study the influence of various anatomical, physical, and physiological factors on aerosol delivery in preterm newborns, it is crucial to have appropriate in vitro models, which are currently not available. We therefore constructed the premature infant nose throat-model (PrINT-Model), an upper airway model corresponding to a premature infant of 32-wk gestational age by three-dimensional (3D) reconstruction of a three-planar magnetic resonance imaging scan and subsequent 3D-printing. Validation was realized by visual comparison and comparison of total airway volume. To study the feasibility of measuring aerosol deposition, budesonide was aerosolized through the cast and lung dose was expressed as percentage of nominal dose. The airway volumes of the initial magnetic resonance imaging and validation computed tomography scan showed a relative deviation of 0.94%. Lung dose at low flow (1 L/min) was 61.84% and 9.00% at high flow (10 L/min), p < 0.0001. 3D-reconstruction provided an anatomically accurate surrogate of the upper airways of a 32-wk-old premature infant, making the model suitable for future in vitro testing.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Paediatric Medicine

UniBE Contributor:

Minocchieri, Stefan; Stern Meggers, Georgette; Kraemer, Richard; Frey, Urs Peter and Nelle, Mathias

ISSN:

0031-3998

ISBN:

18391845

Publisher:

Nature Publishing Group

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 15:03

Last Modified:

04 May 2014 23:19

Publisher DOI:

10.1203/PDR.0b013e318175dcfa

PubMed ID:

18391845

Web of Science ID:

000258022000007

URI:

https://boris.unibe.ch/id/eprint/27193 (FactScience: 104927)

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