Regional and overall ventilation inhomogeneities in preterm and term-born infants

Riedel, Thomas; Kyburz, Manuela; Latzin, Philipp; Thamrin, Cindy; Frey, Urs (2009). Regional and overall ventilation inhomogeneities in preterm and term-born infants. Intensive care medicine, 35(1), pp. 144-51. Berlin: Springer-Verlag 10.1007/s00134-008-1299-x

[img]
Preview
Text
134_2008_Article_1299.pdf - Published Version
Available under License Publisher holds Copyright.

Download (243kB) | Preview

OBJECTIVES: We compared ventilation inhomogeneity assessed by electrical impedance tomography (EIT) and multiple breath washout (MBW) in preterm and term-born infants. We hypothesised that EIT measurements in spontaneously breathing infants are repeatable and that differences in regional ventilation distribution measured by EIT can distinguish between preterm and term-born infants. DESIGN: Cross-sectional group comparison study. SETTING: Lung function laboratory at a University Children's Hospital. PARTICIPANTS: Seventeen healthy term-born and 15 preterm infants at a matched postmenstrual age of 44 weeks. MEASUREMENTS AND RESULTS: We concurrently measured ventilation inhomogeneity by EIT, ventilation inhomogeneity (LCI) and functional residual capacity (FRC) by MBW and tidal breathing variables during unsedated quiet sleep. EIT measurements were highly repeatable (coefficient of variation 3.6%). Preterm infants showed significantly more ventilation of the independent parts of the lungs compared to healthy term-born infants assessed by EIT (mean difference 5.0, 95 CI 1.3-8%). Whereas the two groups showed no differences in lung volumes or ventilation inhomogeneities assessed by MBW, EIT discriminated better between term and preterm infants. (FRC/kg: mean difference 1.1 mL, 95% CI -1.4-3.8 mL; LCI: mean difference 0.03, 95% CI -0.32-0.25). CONCLUSIONS: EIT shows distinct differences in ventilation distribution between preterm and term-born infants, which cannot be detected by MBW. Although preterm infants are capable of dynamically maintaining overall functional residual volume and ventilation distribution, they show some spatial differences from fullterm infants.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Paediatric Medicine

UniBE Contributor:

Riedel, Thomas; Latzin, Philipp; Thamrin, Cindy and Frey, Urs Peter

ISSN:

0342-4642

ISBN:

18810387

Publisher:

Springer-Verlag

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 15:03

Last Modified:

24 Oct 2019 21:45

Publisher DOI:

10.1007/s00134-008-1299-x

PubMed ID:

18810387

Web of Science ID:

000262549100019

BORIS DOI:

10.7892/boris.27197

URI:

https://boris.unibe.ch/id/eprint/27197 (FactScience: 104936)

Actions (login required)

Edit item Edit item
Provide Feedback