Cathepsins: key modulators of cell death and inflammatory responses

Conus, Sébastien; Simon, Hans-Uwe (2008). Cathepsins: key modulators of cell death and inflammatory responses. Biochemical pharmacology, 76(11), pp. 1374-82. New York, N.Y.: Elsevier 10.1016/j.bcp.2008.07.041

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Apoptosis is a key mechanism in the build up and maintenance of both innate and adaptive immunity as well as in the regulation of cellular homeostasis in almost every organ and tissue. Central to the apoptotic process is a family of intracellular cysteine proteases with aspartate-specificity, called caspases. Nevertheless, there is growing evidence that other non-caspase proteases, in particular lysosomal cathepsins, can play an important role in the regulation of apoptosis. In this review, the players and the molecular mechanisms involved in the lysosomal apoptotic pathways will be discussed as well as the importance of these pathways in the immune system and the pathogenesis of diseases.

Item Type:	Journal Article (Further Contribution)
Division/Institute:	04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Pharmacology
UniBE Contributor:	Simon, Hans-Uwe
ISSN:	0006-2952
ISBN:	18762176
Publisher:	Elsevier
Language:	English
Submitter:	Factscience Import
Date Deposited:	04 Oct 2013 15:03
Last Modified:	05 Dec 2022 14:19
Publisher DOI:	10.1016/j.bcp.2008.07.041
PubMed ID:	18762176
Web of Science ID:	000261569400008
URI:	https://boris.unibe.ch/id/eprint/27534 (FactScience: 108752)