Basic and clinical immunology of Siglecs

von Gunten, Stephan; Bochner, Bruce S (2008). Basic and clinical immunology of Siglecs. Annals of the New York Academy of Sciences, 1143, pp. 61-82. Boston, Mass.: Blackwell 10.1196/annals.1443.011

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Siglecs are cell-surface proteins found primarily on hematopoietic cells. By definition, they are members of the immunoglobulin gene super-family and bind sialic acid. Most contain cytoplasmic tyrosine motifs implicated in cell signaling. This review will first summarize characteristics common and unique to Siglecs, followed by a discussion of each human Siglec in numerical order, mentioning in turn its closest murine ortholog or paralog. Each section will describe its pattern of cellular expression, latest known immune functions, ligands, and signaling pathways, with the focus being predominantly on CD33-related Siglecs. Potential clinical and therapeutic implications of each Siglec will also be covered.

Item Type:	Journal Article (Further Contribution)
Division/Institute:	04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Pharmacology
UniBE Contributor:	von Gunten, Stephan
ISSN:	0077-8923
ISBN:	19076345
Publisher:	Blackwell
Language:	English
Submitter:	Factscience Import
Date Deposited:	04 Oct 2013 15:04
Last Modified:	05 Dec 2022 14:19
Publisher DOI:	10.1196/annals.1443.011
PubMed ID:	19076345
Web of Science ID:	000261717900005
URI:	https://boris.unibe.ch/id/eprint/27821 (FactScience: 111667)