Orbital fat atrophy in glaucoma patients treated with topical bimatoprost--can bimatoprost cause enophthalmos?

Tappeiner, Christoph; Perren, Barbara; Iliev, Milko Emilov; Früh Epstein, Beatrice; Goldblum, David (2008). Orbital fat atrophy in glaucoma patients treated with topical bimatoprost--can bimatoprost cause enophthalmos? Klinische Monatsblätter für Augenheilkunde, 225(5), pp. 443-5. Stuttgart: Ferdinand Enke Verlag 10.1055/s-2008-1027362

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PURPOSE: The aim of this communication is to report enophthalmos as a possible new adverse effect of topical bimatoprost treatment. PATIENTS AND METHODS: A retrospective case series of five glaucoma patients under long-term topical bimatoprost treatment was evaluated. Documentation with photo and Hertel exophthalmometry was reviewed. RESULTS: In all five patients a deep lid sulcus, reduced infraocular fat pads and enophthalmos-suspicious Hertel values were found (mean 11.9 mm; SD 2.4). Other aetiologies for enophthalmos were excluded anamnestically and by clinical examination. CONCLUSION: Bimatoprost may lead to an alteration of the eyelid with deepening of the lid sulcus and may also be responsible for an iatrogenic orbital fat atrophy. A possible mechanism of action might be the induction of apoptosis of orbital fibroblasts with a remodelling of the extracellular matrix. Prospective studies are necessary to confirm this cross-sectional observation.

Item Type:

Journal Article (Further Contribution)

Division/Institute:

04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Ophthalmology

UniBE Contributor:

Tappeiner, Christoph; Iliev, Milko Emilov; Früh Epstein, Beatrice and Goldblum, David

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0023-2165

ISBN:

18454393

Publisher:

Ferdinand Enke Verlag

Submitter:

Christoph Tappeiner

Date Deposited:

04 Oct 2013 15:05

Last Modified:

04 May 2014 23:20

Publisher DOI:

10.1055/s-2008-1027362

PubMed ID:

18454393

Web of Science ID:

000256237600031

URI:

https://boris.unibe.ch/id/eprint/28223 (FactScience: 118877)

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