Tappeiner, Christoph; Perren, Barbara; Iliev, Milko Emilov; Früh Epstein, Beatrice; Goldblum, David (2008). Orbital fat atrophy in glaucoma patients treated with topical bimatoprost--can bimatoprost cause enophthalmos? Klinische Monatsblätter für Augenheilkunde, 225(5), pp. 443-5. Stuttgart: Ferdinand Enke Verlag 10.1055/s-2008-1027362
Full text not available from this repository. (Request a copy)PURPOSE: The aim of this communication is to report enophthalmos as a possible new adverse effect of topical bimatoprost treatment. PATIENTS AND METHODS: A retrospective case series of five glaucoma patients under long-term topical bimatoprost treatment was evaluated. Documentation with photo and Hertel exophthalmometry was reviewed. RESULTS: In all five patients a deep lid sulcus, reduced infraocular fat pads and enophthalmos-suspicious Hertel values were found (mean 11.9 mm; SD 2.4). Other aetiologies for enophthalmos were excluded anamnestically and by clinical examination. CONCLUSION: Bimatoprost may lead to an alteration of the eyelid with deepening of the lid sulcus and may also be responsible for an iatrogenic orbital fat atrophy. A possible mechanism of action might be the induction of apoptosis of orbital fibroblasts with a remodelling of the extracellular matrix. Prospective studies are necessary to confirm this cross-sectional observation.
Item Type: |
Journal Article (Further Contribution) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Ophthalmology |
UniBE Contributor: |
Tappeiner, Christoph, Iliev, Milko Emilov, Früh Epstein, Beatrice, Goldblum, David |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
0023-2165 |
ISBN: |
18454393 |
Publisher: |
Ferdinand Enke Verlag |
Submitter: |
Christoph Tappeiner |
Date Deposited: |
04 Oct 2013 15:05 |
Last Modified: |
05 Dec 2022 14:20 |
Publisher DOI: |
10.1055/s-2008-1027362 |
PubMed ID: |
18454393 |
Web of Science ID: |
000256237600031 |
URI: |
https://boris.unibe.ch/id/eprint/28223 (FactScience: 118877) |
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