Cytotoxic diacetylenic spiroketal enol ethers from Plagius flosculosus

Casu, Laura; Bonsignore, Leonardo; Pinna, Manuela; Casu, Mariano; Floris, Costantino; Gertsch, Jürg; Cottiglia, Filippo (2006). Cytotoxic diacetylenic spiroketal enol ethers from Plagius flosculosus. Journal of natural products, 69(2), pp. 295-8. Washington, D.C.: American Chemical Society 10.1021/np0504513

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Three new diacetylenic spiroketal enol ethers named flosculins A (1), B (2), and C (3), along with five known compounds (4-8) of the same structural class, were isolated from the leaves of Plagius flosculosus. The structures were deduced by extensive 1D and 2D NMR spectroscopy and mass spectrometry. All isolated compounds exhibited significant cytotoxic activity against leukemia cells (Jurkat T and HL-60). Compounds 5-8 induced apoptosis in HL-60 cells with corresponding IC(50) values ranging from 4 to 6 microM.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Biochemistry and Molecular Medicine

UniBE Contributor:

Gertsch, Jürg

ISSN:

0163-3864

ISBN:

16499337

Publisher:

American Chemical Society

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 15:05

Last Modified:

04 May 2014 23:20

Publisher DOI:

10.1021/np0504513

PubMed ID:

16499337

Web of Science ID:

000235943400026

URI:

https://boris.unibe.ch/id/eprint/28329 (FactScience: 120063)

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