Effects of a low dose infusion of racemic and S-ketamine on the nociceptive withdrawal reflex in standing ponies

Peterbauer, Christoph; Larenza, Paula M; Knobloch, Monika; Theurillat, Regula; Thormann, Wolfgang; Mevissen, Meike; Spadavecchia, Claudia (2008). Effects of a low dose infusion of racemic and S-ketamine on the nociceptive withdrawal reflex in standing ponies. Veterinary anaesthesia and analgesia, 35(5), pp. 414-23. Oxford: Blackwell Science 10.1111/j.1467-2995.2008.00402.x

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OBJECTIVE: To investigate the effect of plasma concentrations obtained by a low dose constant rate infusion (CRI) of racemic ketamine or S-ketamine on the nociceptive withdrawal reflex (NWR) in standing ponies. STUDY DESIGN: Prospective, blinded, cross-over study. ANIMALS: Six healthy 5-year-old Shetland ponies. METHODS: Ponies received either 0.6 mg kg(-1) racemic ketamine (group RS) or 0.3 mg kg(-1) S-ketamine (group S) intravenously (IV), followed by a CRI of 20 microg kg(-1)minute(-1) racemic ketamine (group RS) or 10 microg kg(-1)minute(-1) S-ketamine (group S) for 59 minutes. The NWR was evoked by transcutaneous electrical stimulation of a peripheral nerve before drug administration, 15 and 45 minutes after the start of the bolus injection and 15 minutes after the end of the CRI. Electromyographic responses were recorded and analysed. Arterial blood was collected before stimulation and plasma concentrations of ketamine and norketamine were measured enantioselectively using capillary electrophoresis. Ponies were video recorded and monitored to assess drug effects on behaviour, heart rate (HR), mean arterial blood pressure (MAP) and respiratory rate. RESULTS: The NWR was significantly depressed in group RS at plasma concentrations between 20 and 25 ng mL(-1) of each enantiomer. In group S, no significant NWR depression could be observed; plasma concentrations of S-ketamine (9-15 ng mL(-1)) were lower, compared to S-ketamine concentrations in group RS, although this difference was not statistically significant. Minor changes in behaviour, HR and MAP only occurred within the first 5-10 minutes after bolus drug administration in both groups. CONCLUSION: Antinociceptive activity in standing ponies, demonstrated as a depression of the NWR, could only be detected after treatment with racemic ketamine. S-ketamine may have lacked this effect as a result of lower plasma concentrations, a more rapid metabolism or a lower potency of S-ketamine in Equidae so further investigation is necessary.

Item Type:

Journal Article (Original Article)

Division/Institute:

05 Veterinary Medicine > Department of Clinical Veterinary Medicine (DKV) > DKV - Anaesthesiology
05 Veterinary Medicine > Department of Clinical Research and Veterinary Public Health (DCR-VPH) > Veterinary Pharmacology and Toxicology
04 Faculty of Medicine > Service Sector > Institute of Clinical Pharmacology and Visceral Research (discontinued)

UniBE Contributor:

Knobloch, Monika; Theurillat, Regula; Thormann, Wolfgang; Mevissen, Meike and Spadavecchia, Claudia

Subjects:

600 Technology > 630 Agriculture

ISSN:

1467-2987

ISBN:

18466162

Publisher:

Blackwell Science

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 15:05

Last Modified:

02 Oct 2014 09:33

Publisher DOI:

10.1111/j.1467-2995.2008.00402.x

PubMed ID:

18466162

Web of Science ID:

000258287600007

URI:

https://boris.unibe.ch/id/eprint/28343 (FactScience: 120165)

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