Tumor suppressor and hepatocellular carcinoma

Martin, Juliette; Dufour, Jean-François (2008). Tumor suppressor and hepatocellular carcinoma. World journal of gastroenterology, 14(11), pp. 1720-33. Beijing (China): WJG Press 10.3748/wjg.14.1720

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A few signaling pathways are driving the growth of hepatocellular carcinoma. Each of these pathways possesses negative regulators. These enzymes, which normally suppress unchecked cell proliferation, are circumvented in the oncogenic process, either the over-activity of oncogenes is sufficient to annihilate the activity of tumor suppressors or tumor suppressors have been rendered ineffective. The loss of several key tumor suppressors has been described in hepatocellular carcinoma. Here, we systematically review the evidence implicating tumor suppressors in the development of hepatocellular carcinoma.

Item Type:	Journal Article (Further Contribution)
Division/Institute:	04 Faculty of Medicine > Department of Gastro-intestinal, Liver and Lung Disorders (DMLL) > Clinic of Visceral Surgery and Medicine > Hepatology 04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Hepatologie 04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Hepatologie 04 Faculty of Medicine > Service Sector > Institute of Clinical Pharmacology and Visceral Research [discontinued]
UniBE Contributor:	Martin, Juliette, Dufour, Jean-François
Subjects:	600 Technology > 610 Medicine & health
ISSN:	1007-9327
ISBN:	18350603
Publisher:	WJG Press
Language:	English
Submitter:	Factscience Import
Date Deposited:	04 Oct 2013 15:05
Last Modified:	05 Dec 2022 14:20
Publisher DOI:	10.3748/wjg.14.1720
PubMed ID:	18350603
Web of Science ID:	000255718500012
URI:	https://boris.unibe.ch/id/eprint/28360 (FactScience: 120276)