Modulation of parvalbumin expression in the motor cortex of parkinsonian rats

Capper-Loup, Christine; Burgunder, Jean-Marc; Kaelin-Lang, Alain (2005). Modulation of parvalbumin expression in the motor cortex of parkinsonian rats. Experimental neurology, 193(1), pp. 234-7. San Diego, Calif.: Elsevier 10.1016/j.expneurol.2004.12.007

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Dopamine deficiency in Parkinson's disease leads to numerous molecular changes in basal ganglia. However, the consequences of these changes on the motor cortex remain unclear. Here we show that the immunoreactivity of parvalbumin, which is expressed in GABAergic interneurons, increases in the primary motor cortex of parkinsonian rats. This increase can be reversed by a subsequent lesion of the subthalamic nucleus. These results suggest that dopamine deficiency induces reversible changes in GABAergic cortical cells, which might be linked with parkinsonian symptoms.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurology

UniBE Contributor:

Kaelin, Alain and Burgunder, Jean-Marc

ISSN:

0014-4886

ISBN:

15817282

Publisher:

Elsevier

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 15:05

Last Modified:

04 May 2014 23:20

Publisher DOI:

10.1016/j.expneurol.2004.12.007

PubMed ID:

15817282

Web of Science ID:

000228413300023

URI:

https://boris.unibe.ch/id/eprint/28381 (FactScience: 120482)

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