Capper-Loup, Christine; Burgunder, Jean-Marc; Kaelin-Lang, Alain (2005). Modulation of parvalbumin expression in the motor cortex of parkinsonian rats. Experimental neurology, 193(1), pp. 234-7. San Diego, Calif.: Elsevier 10.1016/j.expneurol.2004.12.007
Full text not available from this repository.Dopamine deficiency in Parkinson's disease leads to numerous molecular changes in basal ganglia. However, the consequences of these changes on the motor cortex remain unclear. Here we show that the immunoreactivity of parvalbumin, which is expressed in GABAergic interneurons, increases in the primary motor cortex of parkinsonian rats. This increase can be reversed by a subsequent lesion of the subthalamic nucleus. These results suggest that dopamine deficiency induces reversible changes in GABAergic cortical cells, which might be linked with parkinsonian symptoms.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurology |
UniBE Contributor: |
Kaelin, Alain, Burgunder, Jean-Marc |
ISSN: |
0014-4886 |
ISBN: |
15817282 |
Publisher: |
Elsevier |
Language: |
English |
Submitter: |
Factscience Import |
Date Deposited: |
04 Oct 2013 15:05 |
Last Modified: |
05 Dec 2022 14:20 |
Publisher DOI: |
10.1016/j.expneurol.2004.12.007 |
PubMed ID: |
15817282 |
Web of Science ID: |
000228413300023 |
URI: |
https://boris.unibe.ch/id/eprint/28381 (FactScience: 120482) |
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