HLA-Bw4 homozygosity is associated with an impaired CD4 T cell recovery after initiation of antiretroviral therapy

Rauch, Andri; Nolan, David; Furrer, Hansjakob; McKinnon, Elizabeth; John, Mina; Mallal, Simon; Gaudieri, Silvana; Günthard, Huldrych F; Schmid, Patrick; Battegay, Manuel; Hirschel, Bernard; Telenti, Amalio; James, Ian (2008). HLA-Bw4 homozygosity is associated with an impaired CD4 T cell recovery after initiation of antiretroviral therapy. Clinical infectious diseases, 46(12), pp. 1921-5. Cary, N.C.: The University of Chicago Press 10.1086/588479

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We assessed the influence of human leukocyte antigen (HLA) alleles HLA-Bw4 and HLA-Bw6 on CD4 T cell recovery after starting successful combination antiretroviral therapy in 265 individuals. The median gains in the CD4 T cell count after 4 years were 258 cells/microL for HLA-Bw4 homozygotes, 321 cells/microL for HLA-Bw4/Bw6 heterozygotes, and 363 cells/microL for HLA-Bw6 homozygotes (P = .01, compared with HLA-Bw4 homozygotes). HLA-Bw4 homozygosity appears to predict an impaired CD4 T cell recovery after initiation of combination antiretroviral therapy.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Clinic of Infectiology

UniBE Contributor:

Rauch, Andri and Furrer, Hansjakob

ISSN:

1058-4838

ISBN:

18466093

Publisher:

The University of Chicago Press

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 15:06

Last Modified:

27 Apr 2018 11:12

Publisher DOI:

10.1086/588479

PubMed ID:

18466093

Web of Science ID:

000256044900024

BORIS DOI:

10.7892/boris.28680

URI:

https://boris.unibe.ch/id/eprint/28680 (FactScience: 125149)

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