Influence of dextrans on cardiac preservation in an extracorporeal rat heart model

Albes, M; Baumgärtel, I; Rohde, R; Hausen, B; Demertzis, S; Wahlers, T (1995). Influence of dextrans on cardiac preservation in an extracorporeal rat heart model. European surgical research, 6(27), pp. 406-10. Basel: Karger 10.1159/000129427

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Despite advances in preservation techniques for thoracic organs, the ischemic tolerance of the donor heart is still limited. Recently, a beneficial effect of oncotic substances such as dextran was shown in lung transplantation. Clinically, only in the University of Wisconsin (UW) solution oncotic substances for the prevention of cellular edema are used. Since little is known about the perspective value of dextrans in cardiac preservation, we investigated dextrans with different molecular weights added to the St. Thomas Hospital solution in an experimental working rat heart Langendorff model for functional and histological aspects. By comparison of various dextrans with molecular weights of 40,000, 70,000 and 160,000 daltons, best results were achieved by the addition of 5% dextran with the highest molecular weight.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Other Institutions > Teaching Staff, Faculty of Medicine

UniBE Contributor:

Demertzis, Stefanos

ISSN:

0014-312X

ISBN:

8542926

Publisher:

Karger

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 15:08

Last Modified:

04 May 2014 23:21

Publisher DOI:

10.1159/000129427

PubMed ID:

8542926

Web of Science ID:

A1995TB09700007

URI:

https://boris.unibe.ch/id/eprint/29691 (FactScience: 157850)

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