Albes, M; Baumgärtel, I; Rohde, R; Hausen, B; Demertzis, S; Wahlers, T (1995). Influence of dextrans on cardiac preservation in an extracorporeal rat heart model. European surgical research, 6(27), pp. 406-10. Basel: Karger 10.1159/000129427
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Despite advances in preservation techniques for thoracic organs, the ischemic tolerance of the donor heart is still limited. Recently, a beneficial effect of oncotic substances such as dextran was shown in lung transplantation. Clinically, only in the University of Wisconsin (UW) solution oncotic substances for the prevention of cellular edema are used. Since little is known about the perspective value of dextrans in cardiac preservation, we investigated dextrans with different molecular weights added to the St. Thomas Hospital solution in an experimental working rat heart Langendorff model for functional and histological aspects. By comparison of various dextrans with molecular weights of 40,000, 70,000 and 160,000 daltons, best results were achieved by the addition of 5% dextran with the highest molecular weight.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Faculty Institutions > Teaching Staff, Faculty of Medicine |
UniBE Contributor: |
Demertzis, Stefanos |
ISSN: |
0014-312X |
ISBN: |
8542926 |
Publisher: |
Karger |
Language: |
English |
Submitter: |
Factscience Import |
Date Deposited: |
04 Oct 2013 15:08 |
Last Modified: |
21 Jun 2023 15:24 |
Publisher DOI: |
10.1159/000129427 |
PubMed ID: |
8542926 |
Web of Science ID: |
A1995TB09700007 |
BORIS DOI: |
10.48350/29691 |
URI: |
https://boris.unibe.ch/id/eprint/29691 (FactScience: 157850) |
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