Immune cell-mediated liver injury

Corazza, Nadia; Badmann, Anastasia; Lauer, Christoph (2009). Immune cell-mediated liver injury. Seminars in immunopathology, 31(2), pp. 267-277. Berlin: Springer-Verlag 10.1007/s00281-009-0168-1

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Liver diseases represent an important cause of morbidity and mortality in the world. Death of hepatocytes and other hepatic cell types is a characteristic feature of several forms of liver injury such as cholestasis, viral hepatitis, drug- or toxin-induced injury, and alcohol-induced liver damage. Moreover, irrespectively of the reason, liver injury seems to be facilitated by similar immune effector mechanisms common to these various liver diseases. Indeed, common immune effector mechanisms may explain the high prevalence of cirrhosis and cancer development in most forms of liver disease. Improved understanding of the immune cell-mediated mechanisms involved in hepatocyte cell death could be beneficial for the development of common therapeutic strategies against different forms of liver diseases. In this review, we will discuss novel findings on the role of different immune cells in liver disease and immune cell-induced death executioner mechanisms involved in hepatocyte cell death.

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > Service Sector > Institute of Pathology

UniBE Contributor:

Corazza, Nadia; Badmann, Anastasia and Lauer, Christoph

ISSN:

1863-2297

ISBN:

19533131

Publisher:

Springer-Verlag

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 15:08

Last Modified:

13 Sep 2018 14:55

Publisher DOI:

10.1007/s00281-009-0168-1

PubMed ID:

19533131

BORIS DOI:

10.7892/boris.29980

URI:

https://boris.unibe.ch/id/eprint/29980 (FactScience: 165581)

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