FoxP3 positive T cells in graft biopsies from living donor kidney transplants after donor-specific transfusions

Eisenberger, Ute; Seifried, Andrea; Patey, Natacha; Kappeler, Andreas; Noel, Laure-Hélène; Frey, Felix J; Körner, Meike (2009). FoxP3 positive T cells in graft biopsies from living donor kidney transplants after donor-specific transfusions. Transplantation, 87(1), pp. 138-42. Hagerstown, Md.: Lippincott Williams & Wilkins 10.1097/TP.0b013e3181900278

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Donor-specific transfusions (DST) induce allograft tolerance in animals. Evidence is growing that FoxP3+ regulatory T cells are associated with tolerance in humans. Forty-four biopsies from 69 living donor kidney transplant recipients (LDT) after DST, 53 biopsies from 69 matched deceased donor transplant recipients (DDT), obtained for graft dysfunction, and 12 biopsies from LDT without DST were retrospectively analyzed. FoxP3 positivity was more frequent in LDT/DST than in DDT biopsies (67% vs. 44%, P=0.02). Considering only biopsies with acute rejection, FoxP3 positivity was observed in 92% (11/12) after LDT/DST, but only in 50% (6/12) after DDT (P=0.03). The number of FoxP3+ T cells per total infiltrating cells in rejection biopsies was higher (P<0.05) from LDT/DST (4.1%) than from DDT or LDT (2.6%) without DST (2.5%). Six-year graft survival was better in patients with LDT/DST than with DDT (87.5% vs. 79.7%, P=0.04). The present investigation demonstrates an association between DST and FoxP3+ T cells. The effect of DST on regulatory T cells deserves further analysis in transplantation.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Dermatology, Urology, Rheumatology, Nephrology, Osteoporosis (DURN) > Clinic of Nephrology and Hypertension
04 Faculty of Medicine > Service Sector > Institute of Pathology

UniBE Contributor:

Eisenberger, Ute; Kappeler, Andreas; Frey, Felix Julius and Körner Jachertz, Meike

ISSN:

0041-1337

ISBN:

19136904

Publisher:

Lippincott Williams & Wilkins

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 15:08

Last Modified:

04 May 2014 23:21

Publisher DOI:

10.1097/TP.0b013e3181900278

PubMed ID:

19136904

Web of Science ID:

000262483700022

URI:

https://boris.unibe.ch/id/eprint/29993 (FactScience: 165622)

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