Potent and broad-spectrum antimicrobial activity of CXCL14 suggests an immediate role in skin infections

Maerki, Christa; Meuter, Simone; Liebi, Mark; Mühlemann, Kathrin; Frederick, Mitchell J; Yawalkar, Nikhil; Moser, Bernhard; Wolf, Marlene (2009). Potent and broad-spectrum antimicrobial activity of CXCL14 suggests an immediate role in skin infections. Journal of immunology, 182(1), pp. 507-14. Bethesda, Md.: American Association of Immunologists

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The skin is constantly exposed to commensal microflora and pathogenic microbes. The stratum corneum of the outermost skin layer employs distinct tools such as harsh growth conditions and numerous antimicrobial peptides (AMPs) to discriminate between beneficial cutaneous microflora and harmful bacteria. How the skin deals with microbes that have gained access to the live part of the skin as a result of microinjuries is ill defined. In this study, we report that the chemokine CXCL14 is a broad-spectrum AMP with killing activity for cutaneous gram-positive bacteria and Candida albicans as well as the gram-negative enterobacterium Escherichia coli. Based on two separate bacteria-killing assays, CXCL14 compares favorably with other tested AMPs, including human beta-defensin and the chemokine CCL20. Increased salt concentrations and skin-typical pH conditions did not abrogate its AMP function. This novel AMP is highly abundant in the epidermis and dermis of healthy human skin but is down-modulated under conditions of inflammation and disease. We propose that CXCL14 fights bacteria at the earliest stage of infection, well before the establishment of inflammation, and thus fulfills a unique role in antimicrobial immunity.

Item Type:

Journal Article (Original Article)


04 Faculty of Medicine > Service Sector > Institute for Infectious Diseases
04 Faculty of Medicine > Department of Dermatology, Urology, Rheumatology, Nephrology, Osteoporosis (DURN) > Clinic of Dermatology
04 Faculty of Medicine > Pre-clinic Human Medicine > Theodor Kocher Institute

UniBE Contributor:

Mühlemann, Kathrin; Yawalkar, Nikhil and Wolf, Marlene






American Association of Immunologists




Factscience Import

Date Deposited:

04 Oct 2013 15:09

Last Modified:

04 May 2014 23:22

PubMed ID:


Web of Science ID:



https://boris.unibe.ch/id/eprint/30399 (FactScience: 193778)

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