Low-dose recombinant factor VIIa for massive bleeding: A single centre observational cohort study with 73 patients

Schmid, P; Mordasini, A; Luginbühl, M; Regli, B; Kohler, H P; Zimmermann, H; Inderbitzin, D; Hirt, A; Lämmle, B; Alberio, L (2011). Low-dose recombinant factor VIIa for massive bleeding: A single centre observational cohort study with 73 patients. Swiss medical weekly, 141, w13213. Muttenz: EMH Schweizerischer Ärzteverlag 10.4414/smw.2011.13213

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recombinant activated factor VII (rFVIIa) is used off-label for massive bleeding. There is no convincing evidence of the benefits of this practice and the minimal effective dose is unknown. The aim of the study was to evaluate our in-house guideline recommending a low dose of 60 μg/kg for off-label use of rFVIIa.

Item Type:	Journal Article (Original Article)
Division/Institute:	04 Faculty of Medicine > Department of Intensive Care, Emergency Medicine and Anaesthesiology (DINA) > Clinic and Policlinic for Anaesthesiology and Pain Therapy 04 Faculty of Medicine > Department of Intensive Care, Emergency Medicine and Anaesthesiology (DINA) > Clinic of Intensive Care 04 Faculty of Medicine > Department of Intensive Care, Emergency Medicine and Anaesthesiology (DINA) > University Emergency Center 04 Faculty of Medicine > Department of Gastro-intestinal, Liver and Lung Disorders (DMLL) > Clinic of Visceral Surgery and Medicine > Visceral Surgery 04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Clinic of Haematology and Central Haematological Laboratory
UniBE Contributor:	Luginbühl, Martin, Regli, Bruno, Zimmermann, Heinz (B), Inderbitzin, Daniel, Lämmle, Bernhard, Alberio, Lorenzo
ISSN:	1424-7860
Publisher:	EMH Schweizerischer Ärzteverlag
Language:	English
Submitter:	Jeannie Wurz
Date Deposited:	04 Oct 2013 14:13
Last Modified:	29 Mar 2023 23:32
Publisher DOI:	10.4414/smw.2011.13213
PubMed ID:	21735365
Web of Science ID:	000292558000005
URI:	https://boris.unibe.ch/id/eprint/3056 (FactScience: 206332)