Lipids as targets for novel anti-inflammatory therapies

Huwiler, Andrea; Pfeilschifter, Josef (2009). Lipids as targets for novel anti-inflammatory therapies. Pharmacology & therapeutics, 124(1), pp. 96-112. Amsterdam: Elsevier 10.1016/j.pharmthera.2009.06.008

Full text not available from this repository. (Request a copy)

Lipids serve important functions as membrane constituents and also as energy storing molecules. Besides these functions certain lipid species have now been recognized as signalling molecules that regulate a multitude of cellular responses including cell growth and death, and also inflammatory reactions. Bioactive lipids are generated by hydrolysis from membrane lipids mainly by phospholipases giving rise to fatty acids and lysophospholipids that either directly exert their function or are further converted to active mediators. This review will summarize the present knowledge about bioactive lipids that either promote or attenuate inflammatory reactions. These lipids include polyunsaturated fatty acids (PUFA), eicosanoids including the epoxyeicosatrienoic acids (EET), peroxisome proliferation activating receptor (PPAR) activators, cannabinoids and the sphingolipids ceramide, sphingosine 1-phosphate and sphingosylphosphorylcholine.

Item Type:

Journal Article (Further Contribution)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Pharmacology

UniBE Contributor:

Huwiler, Andrea

ISSN:

0163-7258

Publisher:

Elsevier

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 15:10

Last Modified:

06 May 2015 15:33

Publisher DOI:

10.1016/j.pharmthera.2009.06.008

PubMed ID:

19576246

Web of Science ID:

000269873700008

URI:

https://boris.unibe.ch/id/eprint/30674 (FactScience: 194938)

Actions (login required)

Edit item Edit item
Provide Feedback