Regulation of phosphoinositide 3-kinase expression in health and disease

Kok, Klaartje; Geering, Barbara; Vanhaesebroeck, Bart (2009). Regulation of phosphoinositide 3-kinase expression in health and disease. Trends in biochemical sciences, 34(3), pp. 115-27. Cambridge: Elsevier Current Trends 10.1016/j.tibs.2009.01.003

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Both the biology and the therapeutic potential of the phosphoinositide 3-kinase (PI3K) signalling axis have been the subject of intense investigation; however, little is known about the regulation of PI3K expression. Emerging evidence indicates that PI3K levels change in response to cellular stimulation with insulin and nuclear receptor ligands, and during various physiological and pathological processes including differentiation, regeneration, hypertension and cancer. Recently identified mechanisms that control PI3K production include increased gene copy number in cancer, and transcriptional regulation of the p110alpha PI3K gene by FOXO3a, NF-kappaB and p53, and of the PI3K regulatory subunits by STAT3, EBNA-2 and SREBP. In most instances, however, the impact of alterations in PI3K expression on PI3K signalling and disease remains to be established.

Item Type:	Journal Article (Further Contribution)
Division/Institute:	04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Pharmacology
UniBE Contributor:	Geering Truffer, Barbara
ISSN:	0968-0004
Publisher:	Elsevier Current Trends
Language:	English
Submitter:	Factscience Import
Date Deposited:	04 Oct 2013 15:10
Last Modified:	05 Dec 2022 14:21
Publisher DOI:	10.1016/j.tibs.2009.01.003
PubMed ID:	19299143
Web of Science ID:	000265358700007
URI:	https://boris.unibe.ch/id/eprint/30688 (FactScience: 194958)