Rougier, Jean-Sébastien; Muller, Olivier; Berger, Stefan; Centeno, Gabriel; Schütz, Günther; Firsov, Dmitri; Abriel, Hugues (2008). Mineralocorticoid receptor is essential for corticosteroid-induced up-regulation of L-type calcium currents in cultured neonatal cardiomyocytes. Pflügers Archiv : European journal of physiology, 456(2), pp. 407-12. Berlin: Springer 10.1007/s00424-007-0387-z
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Despite the fact that mineralocorticoid receptor (MR) antagonist drugs such as spironolactone and eplerenone reduce the mortality in heart failure patients, there is, thus far, no unambiguous demonstration of a functional role of MR in cardiac cells. The aim of this work was to investigate the activation pathway(s) mediating corticosteroid-induced up-regulation of cardiac calcium current (ICa). In this study, using neonatal cardiomyocytes from MR or glucocorticoid receptor (GR) knockout (KO) mice, we show that MR is essential for corticosteroid-induced up-regulation of ICa. This study provides the first direct and unequivocal evidence for MR function in the heart.
Item Type: |
Journal Article (Original Article) |
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Division/Institute: |
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Ionenkanalkrankheiten 04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Ionenkanalkrankheiten 04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) |
UniBE Contributor: |
Rougier, Jean-Sébastien, Abriel, Hugues |
ISSN: |
0031-6768 |
Publisher: |
Springer |
Language: |
English |
Submitter: |
Factscience Import |
Date Deposited: |
04 Oct 2013 15:10 |
Last Modified: |
05 Dec 2022 14:21 |
Publisher DOI: |
10.1007/s00424-007-0387-z |
PubMed ID: |
18040710 |
Web of Science ID: |
000254906300014 |
BORIS DOI: |
10.48350/30736 |
URI: |
https://boris.unibe.ch/id/eprint/30736 (FactScience: 195025) |
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