Abriel, Hugues

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Ekundayo, Babatunde; Arullampalam, Prakash; Gerber, Christian E.; Hämmerli, Anne-Flore; Guichard, Sabrina; Boukenna, Mey; Ross, Daniela; Lochner, Martin; Rougier, Jean-Sébastien; Stahlberg, Henning; Abriel, Hugues; Ni, Dongchun (23 January 2024). Identification of a Binding Site for Small Molecule Inhibitors Targeting Human TRPM4 (bioRxiv). Cold Spring Harbor Laboratory 10.1101/2024.01.22.576650

Iamshanova, Oksana; Hämmerli, Anne-Flore; Ramaye, Elise; Seljmani, Arbresh; Ross-Kaschitza, Daniela; Schärz, Noëlia; Essers, Maria; Guichard, Sabrina; Rougier, Jean-Sébastien; Abriel, Hugues (2024). The dispensability of 14-3-3 proteins for the regulation of human cardiac sodium channel Nav1.5. PLoS ONE, 19(3) Public Library of Science 10.1371/journal.pone.0298820


Selimi, Zoja; Rougier, Jean-Sébastien; Abriel, Hugues; Kucera, Jan P (2023). A detailed analysis of single-channel Nav 1.5 recordings does not reveal any cooperative gating. The journal of physiology, 601(17), pp. 3847-3868. The Physiological Society 10.1113/JP284861

Iamshanova, Oksana; Rougier, Jean-Sébastien; Abriel, Hugues (2023). Exploring the Oligomerization of Nav1.5 and Its Implication for the Dominant-Negative Effect. Bioelectricity, 5(4), pp. 279-289. Mary Ann Liebert 10.1089/bioe.2023.0014

Boukenna, Mey; Rougier, Jean-Sébastien; Aghagolzadeh, Parisa; Pradervand, Sylvain; Guichard, Sabrina; Hämmerli, Anne-Flore; Pedrazzini, Thierry; Abriel, Hugues (2023). Multiomics uncover the pro-inflammatory role of Trpm4 deletion after myocardial infarction in mice. American journal of physiology - heart and circulatory physiology, 324(4), H504-H518. American Physiological Society 10.1152/ajpheart.00671.2022

Selimi, Zoja; Rougier, Jean-Sébastien; Abriel, Hugues; Kucera, Jan P (2023). No evidence of functional interactions between cardiac sodium channels. Biophysical journal, 122(3 S1), 101a-102a. Elsevier 10.1016/j.bpj.2022.11.736

EL Makhzen, Nada; Daimi, Houria; Bouguenouch, Laila; Abriel, Hugues (2023). The burden of cystic fibrosis in North Africa. Frontiers in genetics, 14 Frontiers Media SA 10.3389/fgene.2023.1295008


Preti, Barbara; Rougier, Jean-Sébastien; Papapostolou, Irida; Bochen, Florian; Gerber, Christian E; Abriel, Hugues; Lochner, Martin; Peinelt, Christine (2022). Targeting Ion Channel TRPM4. CHIMIA, 76(12), pp. 1039-1044. Schweizerische Chemische Gesellschaft 10.2533/chimia.2022.1039

Rossetti, Valentina; Abriel, Hugues (2022). The NCCR TransCure: An Incubator for Interdisciplinary Research. CHIMIA, 76(12), pp. 992-995. Schweizerische Chemische Gesellschaft 10.2533/chimia.2022.992

Abriel, Hugues; Reymond, Jean-Louis (2022). NCCR TransCure - Excellence in Membrane Transport Research from 2010 until 2022. CHIMIA, 76(12), p. 989. Schweizerische Chemische Gesellschaft

Dokshokova, Lolita; Franzoso, Mauro; Bona, Anna Di; Moro, Nicola; Sanchez-Alonso-Mardones, Josè; Prando, Valentina; Sandre, Michele; Basso, Cristina; Faggian, Giuseppe; Abriel, Hugues; Marin, Oriano; Gorelik, Julia; Zaglia, Tania; Mongillo, Marco (2022). Nerve Growth Factor transfer from cardiomyocytes to innervating sympathetic neurons activates TrkA receptors at the neuro-cardiac junction. The journal of physiology, 600(12), pp. 2853-2875. The Physiological Society 10.1113/JP282828


Arullampalam, Prakash; Preti, Barbara; Ross, Daniela; Lochner, Martin; Rougier, Jean-Sébastien; Abriel, Hugues (2021). Species-Specific Effects of Cation Channel TRPM4 Small-Molecule Inhibitors. Frontiers in Pharmacology, 12 Frontiers 10.3389/fphar.2021.712354

Arullampalam, Prakash; Preti, Barbara; Ross-Kaschitza, Daniela; Lochner, Martin; Rougier, Jean-Sébastien; Abriel, Hugues (2 June 2021). Species-specific effects of cation channel TRPM4 small-molecule inhibitors (bioRxiv). Cold Spring Harbor Laboratory 10.1101/2021.06.01.446517

Ozhathil, Lijo Cherian; Rougier, Jean-Sébastien; Arullampalam, Prakash; Essers, Maria C.; Ross-Kaschitza, Daniela; Abriel, Hugues (2021). Deletion of Trpm4 Alters the Function of the Nav1.5 Channel in Murine Cardiac Myocytes. International journal of molecular sciences, 22(7) MDPI 10.3390/ijms22073401

Hu, Yaopeng; Ross Kaschitza, Daniela; Essers, Maria; Arullampalam, Prakash; Fujita, Takayuki; Abriel, Hugues; Inoue, Ryuji (2021). Pathological activation of CaMKII induces arrhythmogenicity through TRPM4 overactivation. Pflügers Archiv : European journal of physiology, 473(3), pp. 507-519. Springer 10.1007/s00424-020-02507-w


Wang, Zizun; Vermij, Sarah H.; Sottas, Valentin; Shestak, Anna; Ross-Kaschitza, Daniela; Zaklyazminskaya, Elena V; Hudmon, Andy; Pitt, Geoffrey S; Rougier, Jean-Sébastien; Abriel, Hugues (2020). Calmodulin binds to the N-terminal domain of the cardiac sodium channel Nav1.5. Channels, 14(1), pp. 268-286. Taylor & Francis 10.1080/19336950.2020.1805999

Vermij, Sarah H.; Rougier, Jean-Sébastien; Agulló-Pascual, Esperanza; Rothenberg, Eli; Delmar, Mario; Abriel, Hugues (2020). Single-Molecule Localization of the Cardiac Voltage-Gated Sodium Channel Reveals Different Modes of Reorganization at Cardiomyocyte Membrane Domains. Circulation. Arrhythmia and electrophysiology, 13(7), pp. 628-639. Lippincott Williams & Wilkins 10.1161/CIRCEP.119.008241

Vermij, S.H.; Abriel, H.; Kucera, J.P. (2020). A fundamental evaluation of the electrical properties and function of cardiac transverse tubules. Biochimica et biophysica acta - molecular cell research, 1867(3), p. 118502. Elsevier 10.1016/j.bbamcr.2019.06.016

Amarouch, Mohamed-Yassine; Kurt, Han; Delemotte, Lucie; Abriel, Hugues (2020). Biophysical Characterization of Epigallocatechin-3-Gallate Effect on the Cardiac Sodium Channel Nav1.5. Molecules, 25(4), p. 902. Molecular Diversity Preservation International MDPI 10.3390/molecules25040902


Gillet, Ludovic; Guichard, Sabrina; Essers, Maria C.; Rougier, Jean-Sébastien; Abriel, Hugues (2019). Dystrophin and calcium current are decreased in cardiomyocytes expressing Cre enzyme driven by αMHC but not TNT promoter. Scientific reports, 9(1), p. 19422. Springer Nature 10.1038/s41598-019-55950-w

Neubauer, Jacqueline; Wang, Zizun; Rougier, Jean-Sébastien; Abriel, Hugues; Rieubland, Claudine; Bartholdi, Deborah; Haas, Cordula; Medeiros-Domingo, Argelia (2019). Functional characterization of a novel SCN5A variant associated with long QT syndrome and sudden cardiac death. International journal of legal medicine, 133(6), pp. 1733-1742. Springer 10.1007/s00414-019-02141-x

Casini, Simona; Albesa, Maxime; Wang, Zizun; Portero, Vincent; Ross-Kaschitza, Daniela; Rougier, Jean-Sébastien; Marchal, Gerard A; Chung, Wendy K; Bezzina, Connie R; Abriel, Hugues; Remme, Carol Ann (2019). Functional Consequences of the SCN5A-p.Y1977N Mutation within the PY Ubiquitylation Motif: Discrepancy between HEK293 Cells and Transgenic Mice. International journal of molecular sciences, 20(20) Molecular Diversity Preservation International MDPI 10.3390/ijms20205033

Delalande, Clémence; Awale, Mahendra; Rubin, Matthias; Probst, Daniel; Ozhathil, Lijo C.; Gertsch, Jürg; Abriel, Hugues; Reymond, Jean-Louis (2019). Optimizing TRPM4 inhibitors in the MHFP6 chemical space. European journal of medicinal chemistry, 166, pp. 167-177. Elsevier 10.1016/j.ejmech.2019.01.048

Marionneau, Céline; Abriel, Hugues (2019). Cardiac Sodium Current Under Sympathetic Control: Protein Phosphatase 2A Regulates Cardiac Na+ Channels. Circulation research, 124(5), pp. 674-676. Lippincott Williams & Wilkins 10.1161/CIRCRESAHA.119.314680

Rougier, Jean-Sébastien; Essers, Maria Cristina; Gillet, Ludovic; Guichard, Sabrina Lucienne Anny; Sonntag, Stephan; Shmerling, Doron; Abriel, Hugues (2019). A Distinct Pool of Nav1.5 Channels at the Lateral Membrane of Murine Ventricular Cardiomyocytes. Frontiers in physiology, 10(834), p. 834. Frontiers Research Foundation 10.3389/fphys.2019.00834

Vermij, Sarah Helena; Abriel, Hugues; Kucera, Jan (2019). Modeling Depolarization Delay, Sodium Currents, and Electrical Potentials in Cardiac Transverse Tubules. Frontiers in physiology, 10(1487) Frontiers Research Foundation 10.3389/fphys.2019.01487


Tamò, Luca; Hibaoui, Youssef; Kallol, Sampada; Alves, Marco; Albrecht, Christiane; Hostettler, Katrin E; Feki, Anis; Rougier, Jean-Sébastien; Abriel, Hugues; Knudsen, Lars; Gazdhar, Amiq; Geiser, Thomas (2018). Generation of an alveolar epithelial type II cell line from induced pluripotent stem cells. American journal of physiology - lung cellular and molecular physiology, 315(6), L921-L932. American Physiological Society 10.1152/ajplung.00357.2017

Chevalier, Morgan Yoann Edwin; Vermij, Sarah Helena; Wyler, Kurt; Gillet, Ludovic; Keller, Irene; Abriel, Hugues (2018). Corrigendum: Transcriptomic analyses of murine ventricular cardiomyocytes. Scientific data, 5(180216), p. 180216. Nature Publishing Group 10.1038/sdata.2018.216

van der Heyden, Marcel A G; Delisle, Brian P; Abriel, Hugues (2018). Editorial: Ion Channel Trafficking and Cardiac Arrhythmias. Frontiers in physiology, 9, p. 1254. Frontiers Research Foundation 10.3389/fphys.2018.01254

Bianchi, Beatrice; Smith, Paul A; Abriel, Hugues (2018). The ion channel TRPM4 in murine experimental autoimmune encephalomyelitis and in a model of glutamate-induced neuronal degeneration. Molecular brain, 11(1), p. 41. BioMed Central 10.1186/s13041-018-0385-4

Ozhathil, Lijo Cherian; Delalande, Clémence Marie Sandrine; Bianchi, Beatrice; Nemeth, Gabor; Kappel, Sven; Thomet, Urs; Ross, Daniela; Simonin, Céline; Rubin, Matthias; Gertsch, Jürg; Lochner, Martin; Peinelt, Christine; Reymond, Jean-Louis; Abriel, Hugues (2018). Identification of potent and selective small molecule inhibitors of the cation channel TRPM4. British journal of pharmacology, 175(12), pp. 2504-2519. Wiley-Blackwell 10.1111/bph.14220

Neubauer, Jacqueline; Rougier, Jean-Sébastien; Abriel, Hugues; Haas, Cordula (2018). Functional implications of a rare variant in the sodium channel β1B subunit () in a 5-month-old male sudden infant death syndrome case. HeartRhythm Case Reports, 4(5), pp. 187-190. Elsevier 10.1016/j.hrcr.2018.01.010

Hichri, Echrak; Abriel, Hugues; Kucera, Jan (2018). Distribution of cardiac sodium channels in clusters potentiates ephaptic interactions in the intercalated disc. Journal of physiology, 596(4), pp. 563-589. Wiley-Blackwell 10.1113/JP275351

Bianchi, Beatrice; Ozhathil, Lijo Cherian; Medeiros Domingo, Argelia; Gollob, Michael H; Abriel, Hugues (2018). Four TRPM4 Cation Channel Mutations Found in Cardiac Conduction Diseases Lead to Altered Protein Stability. Frontiers in physiology, 9, p. 177. Frontiers Research Foundation 10.3389/fphys.2018.00177

Chevalier, Morgan; Vermij, Sarah H.; Wyler, Kurt; Gillet, Ludovic; Keller, Irene; Abriel, Hugues (2018). Transcriptomic analyses of murine ventricular cardiomyocytes. Scientific data, 5(180170), p. 180170. Nature Publishing Group 10.1038/sdata.2018.170


Hinard, Valérie; Britan, Aurore; Schaeffer, Mathieu; Zahn-Zabal, Monique; Thomet, Urs; Rougier, Jean-Sébastien; Bairoch, Amos; Abriel, Hugues; Gaudet, Pascale (2017). Annotation of functional impact of voltage-gated sodium channel mutations. Human mutation, 38(5), pp. 485-493. Wiley-Blackwell 10.1002/humu.23191

Vermij, Sarah Helena; Abriel, Hugues; van Veen, Toon A B (2017). Refining the molecular organization of the cardiac intercalated disc. Cardiovascular research, 113(3), pp. 259-275. Oxford University Press 10.1093/cvr/cvw259


Eichel, Catherine A; Beuriot, Adeline; Chevalier, Morgan Yoann Edwin; Rougier, Jean-Sébastien; Louault, Florent; Dilanian, Gilles; Amour, Julien; Coulombe, Alain; Abriel, Hugues; Hatem, Stéphane N; Balse, Elise (2016). Lateral Membrane-Specific MAGUK CASK Down-Regulates NaV1.5 Channel in Cardiac Myocytes. Circulation research, 119(4), pp. 544-556. Lippincott Williams & Wilkins 10.1161/CIRCRESAHA.116.309254

Mohler, Peter J.; Abriel, Hugues (2016). Complexity of cardiac ion channel macromolecular complexes. Cardiovascular research, 110(2), pp. 163-164. Oxford University Press 10.1093/cvr/cvw055

Syam, Ninda Ratna Maharani; Chatel, Stéphanie; Ozhathil, Lijo Cherian; Sottas, Valentin; Rougier, Jean-Sébastien; Baruteau, Alban; Baron, Estelle; Amarouch, Mohamed Yassine; Daumy, Xavier; Probst, Vincent; Schott, Jean-Jacques; Abriel, Hugues (2016). Variants of Transient Receptor Potential Melastatin Member 4 in Childhood Atrioventricular Block. Journal of the American Heart Association, 5(5) American Heart Association 10.1161/JAHA.114.001625

Daumy, Xavier; Amarouch, Mohamed Yassine; Lindenbaum, Pierre; Bonnaud, Stéphanie; Charpentier, Eric; Bianchi, Beatrice; Nafzger, Sabine Naomi; Baron, Estelle; Fouchard, Swanny; Thollet, Aurélie; Kyndt, Florence; Barc, Julien; Le Scouarnec, Solena; Makita, Naomasa; Le Marec, Hervé; Dina, Christian; Gourraud, Jean-Baptiste; Probst, Vincent; Abriel, Hugues; Redon, Richard; ... (2016). Targeted resequencing identifies TRPM4 as a major gene predisposing to progressive familial heart block type I. International journal of cardiology, 207, pp. 349-358. Elsevier 10.1016/j.ijcard.2016.01.052

Amarouch, Mohamed Yassine; Swan, Heikki; Leinonen, Jaakko; Marjamaa, Annukka; Lahtinen, Annukka M.; Kontula, Kimmo; Toivonen, Lauri; Widen, Elisabeth; Abriel, Hugues (2016). Antiarrhythmic Action of Flecainide in Polymorphic Ventricular Arrhythmias Caused by a Gain-of-Function Mutation in the Na v 1.5 Sodium Channel. Annals of noninvasive electrocardiology, 21(4), pp. 343-351. Wiley 10.1111/anec.12312

Hinard, V; Britan, A; Rougier, Jean-Sébastien; Bairoch, A; Abriel, Hugues; Gaudet, P (2016). ICEPO: the ion channel electrophysiology ontology. Database : the journal of biological databases and curation, 2016 Oxford University Press 10.1093/database/baw017


Abriel, Hugues; Rougier, Jean-Sébastien; Jalife, José (2015). Ion channel macromolecular complexes in cardiomyocytes: roles in sudden cardiac death. Circulation research, 116(12), pp. 1971-1988. Lippincott Williams & Wilkins 10.1161/CIRCRESAHA.116.305017

Marionneau, Céline; Abriel, Hugues (2015). Regulation of the cardiac Na+ channel NaV1.5 by post-translational modifications. Journal of molecular and cellular cardiology, 82, pp. 36-47. Elsevier 10.1016/j.yjmcc.2015.02.013

Chen-Izu, Ye; Shaw, Robin M; Pitt, Geoffrey S; Yarov-Yarovoy, Vladimir; Sack, Jon T; Abriel, Hugues; Aldrich, Richard W; Belardinelli, Luiz; Cannell, Mark B; Catterall, William A; Chazin, Walter J; Chiamvimonvat, Nipavan; Deschenes, Isabelle; Grandi, Eleonora; Hund, Thomas J; Izu, Leighton T; Maier, Lars S; Maltsev, Victor A; Marionneau, Celine; Mohler, Peter J; ... (2015). Na+ channel function, regulation, structure, trafficking and sequestration. Journal of physiology, 593(6), pp. 1347-1360. Wiley-Blackwell 10.1113/jphysiol.2014.281428

Ossola, Dario; Amarouch, Mohamed Yassine; Behr, Pascal; Vörös, János; Abriel, Hugues; Zambelli, Tomaso (2015). Force-controlled patch clamp of beating cardiac cells. Nano letters, 15(3), pp. 1743-1750. American Chemical Society 10.1021/nl504438z

Suter, Marc; Bhuiyan, Zahurul A; Laedermann, Cédric; Kuntzer, Thierry; Schaller, Muriel; Stauffacher, Maurice W; Roulet, Eliane; Abriel, Hugues; Decosterd, Isabelle; Wider, Christian (2015). p.L1612P, a Novel Voltage-gated Sodium Channel Nav1.7 Mutation Inducing a Cold Sensitive Paroxysmal Extreme Pain Disorder. Anesthesiology, 122(2), pp. 414-423. Lippincott Williams & Wilkins 10.1097/ALN.0000000000000476

Saber, Siamak; Amarouch, Mohamed Yassine; Fazelifar, Amir-Farjam; Haghjoo, Majid; Emkanjoo, Zahra; Alizadeh, Abolfath; Houshmand, Massoud; Gavrilenko, Alexander V; Abriel, Hugues; Zaklyazminskaya, Elena V (2015). Complex genetic background in a large family with Brugada syndrome. Physiological reports, 3(1) The American Physiological Society 10.14814/phy2.12256

Gillet, Ludovic; Rougier, Jean-Sébastien; Shy, Diana Amy; Sonntag, Stephan; Mougenot, Nathalie; Essers, Maria Cristina; Shmerling, Doron; Balse, Elise; Hatem, Stéphane N; Abriel, Hugues (2015). Cardiac-specific ablation of synapse-associated protein SAP97 in mice decreases potassium currents but not sodium current. Heart rhythm, 12(1), pp. 181-192. Elsevier 10.1016/j.hrthm.2014.09.057

Baruteau, Alban-Elouen; Probst, Vincent; Abriel, Hugues (2015). Inherited progressive cardiac conduction disorders. Current opinion in cardiology, 30(1), pp. 33-39. Lippincott Williams & Wilkins 10.1097/HCO.0000000000000134

Abriel, H. (2015). Genetic background of Brugada syndrome is more complex than what we would like it to be! Cardiovascular research, 106(3), pp. 351-352. Oxford University Press 10.1093/cvr/cvv135

Amarouch, Mohamed Yassine; Abriel, Hugues (2015). Cellular hyper-excitability caused by mutations that alter the activation process of voltage-gated sodium channels. Frontiers in physiology, 6(45), p. 45. Frontiers Research Foundation 10.3389/fphys.2015.00045

Laedermann, Cédric; Abriel, Hugues; Decosterd, Isabelle (2015). Post-translational modifications of voltage-gated sodium channels in chronic pain syndromes. Frontiers in Pharmacology, 6(263), p. 263. Frontiers 10.3389/fphar.2015.00263


Rougier, Jean-Sébastien; Albesa, Maxime; Syam, Ninda Ratna Maharani; Halet, Guillaume; Abriel, Hugues; Viard, Patricia (2014). Ubiquitin-specific protease USP2-45 acts as a molecular switch to promote α2δ-1-induced downregulation of Ca v1.2 channels. Pflügers Archiv : European journal of physiology, 467(9), pp. 1919-1929. Springer 10.1007/s00424-014-1636-6

Laedermann, Cédric J; Decosterd, Isabelle; Abriel, Hugues (2014). Ubiquitylation of voltage-gated sodium channels. In: Ruben, Peter C. (ed.) Voltage Gated Sodium Channels. Handbook of Experimental Pharmacology: Vol. 221 (pp. 231-250). Springer 10.1007/978-3-642-41588-3_11

Shy, Diana Amy; Gillet, Ludovic; Ogrodnik, Jakob; Albesa, Maxime; Verkerk, Arie O; Wolswinkel, Rianne; Rougier, Jean-Sébastien; Barc, Julien; Essers, Maria Cristina; Syam, Ninda Ratna Maharani; Marsman, Roos F; van Mil, Anneke M; Rotman, Samuel; Redon, Richard; Bezzina, Connie R; Remme, Carol Ann; Abriel, Hugues (2014). PDZ domain-binding motif regulates cardiomyocyte compartment-specific NaV1.5 channel expression and function. Circulation, 130(2), pp. 147-160. Lippincott Williams & Wilkins 10.1161/CIRCULATIONAHA.113.007852

Abriel, Hugues; Sottas, Valentin (2014). Unexpected α-α interactions with NaV1.5 genetic variants in Brugada syndrome. Circulation - cardiovascular genetics, 7(2), pp. 97-99. Lippincott Williams & Wilkins 10.1161/CIRCGENETICS.114.000590

Clemençon, Benjamin; Fine, Michael; Lüscher, Benjamin; Baumann, Marc; Surbek, Daniel; Abriel, Hugues; Hediger, Matthias (2014). Expression, purification, and projection structure by single particle electron microscopy of functional human TRPM4 heterologously expressed in Xenopus laevis oocytes. Protein expression and purification, 95, pp. 169-176. Elsevier 10.1016/j.pep.2013.11.017

Swan, H.; Amarouch, Mohamed Yassine; Leinonen, J.; Marjamaa, A.; Kucera, Jan; Laitinen-Forsblom, P. J.; Lahtinen, A. M.; Palotie, A.; Kontula, K.; Toivonen, L.; Abriel, Hugues; Widen, E. (2014). Gain-of-Function Mutation of the SCN5A Gene Causes Exercise-Induced Polymorphic Ventricular Arrhythmias. Circulation - cardiovascular genetics, 7(6), pp. 771-781. Lippincott Williams & Wilkins 10.1161/CIRCGENETICS.114.000703

Chevalier, Morgan Yoann Edwin; Amuzescu, Bogdan; Gawali, Vaibhavkumar; Todt, Hannes; Knott, Thomas; Scheel, Olaf; Abriel, Hugues (2014). Late cardiac sodium current can be assessed using automated patch-clamp. F1000Research, 3(245), p. 245. F1000 Research Ltd 10.12688/f1000research.5544.1

Syam, Ninda Ratna Maharani; Rougier, Jean-Sébastien; Abriel, Hugues (2014). Glycosylation of TRPM4 and TRPM5 channels: molecular determinants and functional aspects. Frontiers in cellular neuroscience, 8, p. 52. Frontiers Research Foundation 10.3389/fncel.2014.00052

Gillet, L.; Shy, D.; Abriel, H. (2014). Elucidating sodium channel NaV1.5 clustering in cardiac myocytes using super-resolution techniques. Cardiovascular research, 104(2), pp. 231-233. Oxford University Press 10.1093/cvr/cvu221


Andersen, Martin Nybo; Krzystanek, Katarzyna; Petersen, Frederic; Bomholtz, Sofia Hammami; Olesen, Søren-Peter; Abriel, Hugues; Jespersen, Thomas; Rasmussen, Hanne Borger (2013). A phosphoinositide 3-kinase (PI3K)-serum- and glucocorticoid-inducible kinase 1 (SGK1) pathway promotes Kv7.1 channel surface expression by inhibiting Nedd4-2 protein. Journal of biological chemistry, 288(52), pp. 36841-54. American Society for Biochemistry and Molecular Biology 10.1074/jbc.M113.525931

Abriel, Hugues; De Lange, Enno Karel; Kucera, Jan; Loussouarn, Gildas; Tarek, Mounir (2013). Computational tools to investigate genetic cardiac channelopathies. Frontiers in physiology, 4, p. 390. Frontiers Research Foundation 10.3389/fphys.2013.00390

Abriel, Hugues; Rougier, Jean-Sébastien (2013). β-Blockers in Congenital Short-QT Syndrome as Ion Channel Blockers. Journal of cardiovascular electrophysiology, 24(10), pp. 1172-1174. Wiley-Blackwell 10.1111/jce.12204

Sottas, Valentin; Rougier, Jean-Sébastien; Jousset, Florian; Kucera, Jan P.; Shestak, Anna; Makarov, Leonid M.; Zaklyazminskaya, Elena V.; Abriel, Hugues (2013). Characterization of 2 genetic variants of Na(v) 1.5-arginine 689 found in patients with cardiac arrhythmias. Journal of cardiovascular electrophysiology, 24(9), pp. 1037-1046. Wiley-Blackwell 10.1111/jce.12173

Pérez López, Irene; Cariolato, Luca; Maric, Darko; Gillet, Ludovic; Abriel, Hugues; Diviani, Dario (2013). A-kinase anchoring protein Lbc coordinates a p38 activating signaling complex controlling compensatory cardiac hypertrophy. Molecular and cellular biology, 33(15), pp. 2903-2917. American Society for Microbiology 10.1128/MCB.00031-13

Singhanat, Suradech; Ruepp, Marc-David; Jack, Thomas; Rougier, Jean-Sébastien; Abriel, Hugues; Mühlemann, Oliver; Lochner, Martin (August 2013). Towards the site-specific modification of the hERG K+ channel. CHIMIA, 67(7/8), p. 532. Schweizerische Chemische Gesellschaft

Gillet, Ludovic; Shy, Diana Amy; Abriel, Hugues (2013). NaV1.5 and interacting proteins in human arrhythmogenic cardiomyopathy. Future cardiology, 9(4), pp. 467-470. Future Medicine Ltd 10.2217/fca.13.38

Laedermann, Cédric; Cachemaille, Matthieu; Kirschmann, Guylène; Pertin, Marie; Gosselin, Romain-Daniel; Chang, Isabelle; Albesa, Maxime; Towne, Chris; Schneider, Bernard L.; Kellenberger, Stephan; Abriel, Hugues; Decosterd, Isabelle (2013). Dysregulation of voltage-gated sodium channels by ubiquitin ligase NEDD4-2 in neuropathic pain. Journal of clinical investigation, 123(7), pp. 3002-3013. American Society for Clinical Investigation 10.1172/JCI68996

Pouly, Daniel; Debonneville, Anne; Ruffieux-Daidié, Dorothée; Maillard, Marc; Abriel, Hugues; Loffing, Johannes; Staub, Olivier (2013). Mice carrying ubiquitin-specific protease 2 (Usp2) gene inactivation maintain normal sodium balance and blood pressure. American journal of physiology - renal physiology, 305(1), F21-30. American Physiological Society 10.1152/ajprenal.00012.2013

Amarouch, Mohamed Yassine; Syam, Ninda Ratna Maharani; Abriel, Hugues (2013). Biochemical, single-channel, whole-cell patch clamp, and pharmacological analyses of endogenous TRPM4 channels in HEK293 cells. Neuroscience letters, 541, pp. 105-110. Elsevier 10.1016/j.neulet.2013.02.011

Rougier, Jean-Sébastien; Gavillet, Bruno; Abriel, Hugues (2013). Proteasome inhibitor (MG132) rescues Nav1.5 protein content and the cardiac sodium current in dystrophin-deficient mdx (5cv) mice. Frontiers in physiology, 4, p. 51. Frontiers Research Foundation 10.3389/fphys.2013.00051

Reinhard, Katja; Rougier, Jean-Sébastien; Ogrodnik, Jakob; Abriel, Hugues (2013). Electrophysiological properties of mouse and epitope-tagged human cardiac sodium channel Na v1.5 expressed in HEK293 cells. F1000Research, 2(48), p. 48. F1000 Research Ltd 10.12688/f1000research.2-48.v2

Liu, Hui; Chatel, Stéphanie; Simard, Christophe; Syam, Ninda; Salle, Laurent; Probst, Vincent; Morel, Julie; Millat, Gilles; Lopez, Michel; Abriel, Hugues; Schott, Jean-Jacques; Guinamard, Romain; Bouvagnet, Patrice (2013). Molecular genetics and functional anomalies in a series of 248 Brugada cases with 11 mutations in the TRPM4 channel. PLoS ONE, 8(1), e54131. Public Library of Science 10.1371/journal.pone.0054131

Abriel, Hugues; Zaklyazminskaya, Elena V (2013). Cardiac channelopathies: genetic and molecular mechanisms. Gene, 517(1), pp. 1-11. Amsterdam: Elsevier 10.1016/j.gene.2012.12.061

Shy, Diana; Gillet, Ludovic; Abriel, Hugues (2013). Cardiac sodium channel NaV1.5 distribution in myocytes via interacting proteins: the multiple pool model. Biochimica et biophysica acta, 1833(4), pp. 886-94. Amsterdam: Elsevier 10.1016/j.bbamcr.2012.10.026

Laedermann, Cédric J; Syam, Ninda; Pertin, Marie; Decosterd, Isabelle; Abriel, Hugues (2013). β1- and β3- voltage-gated sodium channel subunits modulate cell surface expression and glycosylation of Nav1.7 in HEK293 cells. Frontiers in cellular neuroscience, 7, p. 137. Lausanne: Frontiers Research Foundation 10.3389/fncel.2013.00137


Suter, Marc R.; Kirschmann, Guylène; Laedermann, Cedric J.; Abriel, Hugues; Decosterd, Isabelle (2012). Rufinamide attenuates mechanical allodynia in a model of neuropathic pain in the mouse and stabilizes voltage-gated sodium channel inactivated state. Anesthesiology, 118(1), pp. 160-172. Hagerstown, Md.: Lippincott Williams & Wilkins 10.1097/ALN.0b013e318278cade

Krzystanek, Katarzyna; Rasmussen, Hanne Borger; Grunnet, Morten; Staub, Olivier; Olesen, Søren-Peter; Abriel, Hugues; Jespersen, Thomas (2012). Deubiquitylating enzyme USP2 counteracts Nedd4-2-mediated downregulation of KCNQ1 potassium channels. Heart, 9(3), pp. 440-8. London: BMJ Publishing Group 10.1016/j.hrthm.2011.10.026

Abriel, Hugues (2012). Cardiac Sodium Channel Nav1.5 Mechanosensitivity is Inhibited by Ranolazine. Circulation, 125(22), pp. 2681-3. Baltimore, Md.: Lippincott Williams & Wilkins 10.1161/CIRCULATIONAHA.112.110908

Zaklyazminskaya, Elena V; Abriel, Hugues (2012). Prevalence of Significant Genetic Variants in Congenital Long QT Syndrome is Largely Underestimated. Frontiers in Pharmacology, 3, p. 72. Frontiers 10.3389/fphar.2012.00072

Abriel, Hugues; Zaklyazminskaya, Elena V (2012). A modern approach to classify missense mutations in cardiac channelopathy genes. Circulation - cardiovascular genetics, 5(5), pp. 487-9. Hagerstown, Md.: Lippincott Williams & Wilkins 10.1161/CIRCGENETICS.112.964809

Cachemaille, M; Laedermann, C J; Pertin, M; Abriel, H; Gosselin, R-D; Decosterd, I (2012). Neuronal expression of the ubiquitin ligase Nedd4-2 in rat dorsal root ganglia: modulation in the spared nerve injury model of neuropathic pain. Neuroscience, 227, pp. 370-380. Oxford: Elsevier 10.1016/j.neuroscience.2012.09.044

Rougier, Jean-Sébastien; Abriel, Hugues (2012). Role of "non-cardiac" voltage-gated sodium channels in cardiac cells. Journal of molecular and cellular cardiology, 53(5), pp. 589-90. Oxford: Elsevier 10.1016/j.yjmcc.2012.08.011

Rougier, Jean-Sébastien; Abriel, Hugues (2012). Unexpected dominance: Brugada syndrome SCN5A variants exert negative dominance via α-subunit interaction. Cardiovascular research, 96(1), pp. 1-3. Oxford: Oxford University Press 10.1093/cvr/cvs264

Hersch, Micha; Peter, Bastian; Kang, Hyun Min; Schüpfer, Fanny; Abriel, Hugues; Pedrazzini, Thierry; Eskin, Eleazar; Beckmann, Jacques S; Bergmann, Sven; Maurer, Fabienne (2012). Mapping genetic variants associated with beta-adrenergic responses in inbred mice. PLoS ONE, 7(7), e41032. Lawrence, Kans.: Public Library of Science 10.1371/journal.pone.0041032

Balse, Elise; Steele, David F; Abriel, Hugues; Coulombe, Alain; Fedida, David; Hatem, Stéphane N (2012). Dynamic of ion channel expression at the plasma membrane of cardiomyocytes. Physiological reviews, 92(3), pp. 1317-58. Bethesda, Md.: American Physiological Society 10.1152/physrev.00041.2011

Abriel, Hugues; Syam, Ninda; Sottas, Valentin; Amarouch, Mohamed Yassine; Rougier, Jean-Sébastien (2012). TRPM4 channels in the cardiovascular system: physiology, pathophysiology, and pharmacology. Biochemical pharmacology, 84(7), pp. 873-81. New York, N.Y.: Elsevier 10.1016/j.bcp.2012.06.021


Sintra Grilo, Liliana; Carrupt, Pierre-Alain; Abriel, Hugues; Daina, Antoine (2011). Block of the hERG channel by bupivacaine: Electrophysiological and modeling insights towards stereochemical optimization. European journal of medicinal chemistry, 46(8), pp. 3486-98. Paris: Elsevier Masson SAS 10.1016/j.ejmech.2011.05.015

Grilo, Liliana Sintra; Schläpfer, Jürg; Fellmann, Florence; Abriel, Hugues (2011). Patient with syncope and LQTS carrying a mutation in the PAS domain of the hERG1 channel. Annals of noninvasive electrocardiology, 16(2), pp. 213-8. Oxford: Wiley 10.1111/j.1542-474X.2011.00419.x

Albesa, Maxime; Grilo, Liliana Sintra; Gavillet, Bruno; Abriel, Hugues (2011). Nedd4-2-dependent ubiquitylation and regulation of the cardiac potassium channel hERG1. Journal of molecular and cellular cardiology, 51(1), pp. 90-8. Oxford: Elsevier 10.1016/j.yjmcc.2011.03.015

Templin, Christian; Ghadri, Jelena-Rima; Rougier, Jean-Sébastien; Baumer, Alessandra; Kaplan, Vladimir; Albesa, Maxime; Sticht, Heinrich; Rauch, Anita; Puleo, Colleen; Hu, Dan; Barajas-Martinez, Héctor; Antzelevitch, Charles; Lüscher, Thomas F; Abriel, Hugues; Duru, Firat (2011). Identification of a novel loss-of-function calcium channel gene mutation in short QT syndrome (SQTS6). European Heart Journal, 32(9), pp. 1077-88. Oxford: Oxford University Press 10.1093/eurheartj/ehr076

Rougier, Jean-Sebastien; Albesa, Maxime; Abriel, Hugues; Viard, Patricia (2011). Neuronal precursor cell-expressed developmentally down-regulated 4-1 (NEDD4-1) controls the sorting of newly synthesized Ca(V)1.2 calcium channels. Journal of biological chemistry, 286(11), pp. 8829-38. Bethesda, Md.: American Society for Biochemistry and Molecular Biology 10.1074/jbc.M110.166520

Petitprez, Séverine; Zmoos, Anne-Flore; Ogrodnik, Jakob; Balse, Elise; Raad, Nour; El-Haou, Said; Albesa, Maxime; Bittihn, Philip; Luther, Stefan; Lehnart, Stephan E; Hatem, Stéphane N; Coulombe, Alain; Abriel, Hugues (2011). SAP97 and dystrophin macromolecular complexes determine two pools of cardiac sodium channels Nav1.5 in cardiomyocytes. Circulation research, 108(3), pp. 294-304. Baltimore, Md.: Lippincott Williams & Wilkins 10.1161/CIRCRESAHA.110.228312

Albesa, Maxime; Ogrodnik, Jakob; Rougier, Jean-Sébastien; Abriel, Hugues (2011). Regulation of the cardiac sodium channel Nav1.5 by utrophin in dystrophin-deficient mice. Cardiovascular research, 89(2), pp. 320-8. Oxford: Oxford University Press 10.1093/cvr/cvq326


Stirnimann, Guido; Petitprez, Séverine; Abriel, Hugues; Schwick, Nicola Gillian (2010). Brugada syndrome ECG provoked by the selective serotonin reuptake inhibitor fluvoxamine. Europace, 12(2), pp. 282-283. Oxford: Oxford University Press 10.1093/europace/eup332

Rougier, Jean-Sébastien; Albesa, Maxime; Abriel, Hugues (2010). Ubiquitylation and SUMOylation of Cardiac Ion Channels. Journal of cardiovascular pharmacology, 56(1), pp. 22-28. Hagerstown, Md.: Wolters Kluwer Lippincott Williams & Wilkins 10.1097/FJC.0b013e3181daaff9

Leoni, Anne-Laure; Gavillet, Bruno; Rougier, Jean-Sébastien; Marionneau, Céline; Probst, Vincent; Le Scouarnec, Solena; Schott, Jean-Jacques; Demolombe, Sophie; Bruneval, Patrick; Huang, Christopher L H; Colledge, William H; Grace, Andrew A; Le Marec, Hervé; Wilde, Arthur A; Mohler, Peter J; Escande, Denis; Abriel, Hugues; Charpentier, Flavien (2010). Variable Na(v)1.5 protein expression from the wild-type allele correlates with the penetrance of cardiac conduction disease in the Scn5a(+/-) mouse model. PLoS ONE, 5(2), e9298. Lawrence, Kans.: Public Library of Science 10.1371/journal.pone.0009298

Grilo, Liliana Sintra; Pruvot, Etienne; Grobéty, Michel; Castella, Vincent; Fellmann, Florence; Abriel, Hugues (2010). Takotsubo cardiomyopathy and congenital long QT syndrome in a patient with a novel duplication in the Per-Arnt-Sim (PAS) domain of hERG1. Heart, 7(2), pp. 260-5. London: BMJ Publishing Group 10.1016/j.hrthm.2009.09.026

Abriel, Hugues (2010). Cardiac sodium channel Na(v)1.5 and interacting proteins: Physiology and pathophysiology. Journal of molecular and cellular cardiology, 48(1), pp. 2-11. Oxford: Elsevier 10.1016/j.yjmcc.2009.08.025

Pignier, C; Rougier, JS; Vié, B; Culié, C; Verscheure, Y; Vacher, B; Abriel, H; Le Grand, B (2010). Selective inhibition of persistent sodium current by F 15845 prevents ischaemia-induced arrhythmias. British journal of pharmacology, 161(1), pp. 79-91. Oxford: Wiley-Blackwell 10.1111/j.1476-5381.2010.00884.x

Grilo, Liliana Sintra; Carrupt, Pierre-Alain; Abriel, Hugues (2010). Stereoselective Inhibition of the hERG1 Potassium Channel. Frontiers in Pharmacology, 1, p. 137. Frontiers 10.3389/fphar.2010.00137


El-Haou, Saïd; Balse, Elise; Neyroud, Nathalie; Dilanian, Gilles; Gavillet, Bruno; Abriel, Hugues; Coulombe, Alain; Jeromin, Andreas; Hatem, Stéphane N (2009). Kv4 Potassium Channels Form a Tripartite Complex With the Anchoring Protein SAP97 and CaMKII in Cardiac Myocytes. Circulation research, 2009(104 (6)), pp. 758-69. Baltimore, Md.: Lippincott Williams & Wilkins 10.1161/CIRCRESAHA.108.191007

Berthonneche, Corinne; Peter, Bastian; Schüpfer, Fanny; Hayoz, Pamela; Kutalik, Zoltán; Abriel, Hugues; Pedrazzini, Thierry; Beckmann, Jacques S; Bergmann, Sven; Maurer, Fabienne (2009). Cardiovascular response to beta-adrenergic blockade or activation in 23 inbred mouse strains. PLoS ONE, 4(8), e6610. Lawrence, Kans.: Public Library of Science 10.1371/journal.pone.0006610

Tfelt-Hansen, J; Jespersen, T; Hofman-Bang, J; Rasmussen, H Borger; Cedergreen, P; Skovby, F; Abriel, H; Svendsen, J Hastrup; Olesen, Soren-Peter; Christiansen, M; Haunso, S (2009). Ventricular tachycardia in a Brugada syndrome patient caused by a novel deletion in SCN5A. Canadian journal of cardiology, 25(3), pp. 156-60. Oakville (Canada): Canadian Cardiology Publications 10.1016/S0828-282X(09)70043-1

Kurokawa, Junko; Abriel, Hugues (2009). Neurohormonal regulation of cardiac ion channels in chronic heart failure. Journal of cardiovascular pharmacology, 54(2), pp. 98-105. Hagerstown, Md.: Wolters Kluwer Lippincott Williams & Wilkins 10.1097/FJC.0b013e3181b2b6d4

Michaud, K; Fellmann, F; Abriel, H; Beckmann, JS; Mangin, P; Elger, BS (2009). Molecular autopsy in sudden cardiac death and its implication for families: discussion of the practical, legal and ethical aspects of the multidisciplinary collaboration. Swiss medical weekly, 2009(139 (49-50)), pp. 712-8. Muttenz: EMH Schweizerischer Ärzteverlag


Petitprez, S; Jespersen, T; Pruvot, E; Keller, D I; Corbaz, C; Schläpfer, J; Abriel, H; Kucera, J P (2008). Analysis of a novel SCN5A mutation (C1850S): conduction vs. repolarization disorder hypotheses in the Brugada syndrome. Cardiovascular research, 78(3), pp. 494-504. Oxford: Oxford University Press 10.1093/cvr/cvn023

Rougier, Jean-Sébastien; Muller, Olivier; Berger, Stefan; Centeno, Gabriel; Schütz, Günther; Firsov, Dmitri; Abriel, Hugues (2008). Mineralocorticoid receptor is essential for corticosteroid-induced up-regulation of L-type calcium currents in cultured neonatal cardiomyocytes. Pflügers Archiv : European journal of physiology, 456(2), pp. 407-12. Berlin: Springer 10.1007/s00424-007-0387-z

Petitprez, S; Tiab, L; Chen, Lie; Kappeler, Liliane; Rösler, Kai Michael; Schorderet, D; Abriel, Hugues; Burgunder, Jean-Marc (2008). A novel dominant mutation of the Nav1.4 {alpha}-subunit domain I leading to sodium channel myotonia. Neurology, 71(21), pp. 1669-1675. Hagerstown, Md.: Lippincott Williams & Wilkins 10.1212/01.wnl.0000335168.86248.55

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