In vitro tests in drug hypersensitivity diagnosis

Lochmatter, Priska; Zawodniak, Anna; Pichler, Werner J (2009). In vitro tests in drug hypersensitivity diagnosis. Immunology and allergy clinics of North America, 29(3), pp. 537-54. Philadelphia, Pa.: Elsevier 10.1016/j.iac.2009.04.009

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The diagnosis of a drug hypersensitivity reaction (DHR) is a challenging task because multiple and complex mechanisms are involved. Better understanding of immunologic pathomechanisms in DHRs and rapid progress in cellular-based in-vitro tests can help to adjust the correct diagnostic strategy to individual patients with different clinical manifestations of drug allergy. Thus, drug hypersensitivity diagnosis needs to rely on a combination of medical history and different in vivo and in vitro tests. In this article, the authors discuss current in vitro techniques, most recent findings, and new promising tools in the diagnosis of T-cell-mediated drug hypersensitivity.

Item Type:	Journal Article (Original Article)
Division/Institute:	04 Faculty of Medicine > Department of Dermatology, Urology, Rheumatology, Nephrology, Osteoporosis (DURN) > Clinic of Rheumatology and Immunology
UniBE Contributor:	Pichler, Werner Joseph
ISSN:	0889-8561
Publisher:	Elsevier
Language:	English
Submitter:	Factscience Import
Date Deposited:	04 Oct 2013 15:11
Last Modified:	05 Dec 2022 14:22
Publisher DOI:	10.1016/j.iac.2009.04.009
PubMed ID:	19563996
Web of Science ID:	000268560300011
URI:	https://boris.unibe.ch/id/eprint/31426 (FactScience: 195936)